NCT07105891进行中（未招募）不适用
Optimization of Oocyte Warming Protocols: a Comparative Study of Standard, Rapid, and Ultra-rapid Techniques on Oocyte Survival Rate and Spindle Morphometry
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 399
- 试验地点
- 2
- 主要终点
- Oocytes Survival rate
研究概览
简要总结
This is a retrospective study with a sibling design comparing new oocyte thawing protocols (rapid and ultra-rapid) with the traditional method
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Vitrified oocytes from the Centro Scienze della Natalità, IRCCS San Raffaele Hospital
- •Patients who explicitly consented to the disposal of their stored gametes and authorized their use for research purposes through the informed consent process
- •Oocytes cryopreserved using the vitrification technique
- •Patients age 20-39 yo
排除标准
- •All oocytes cryopreserved using the slow freezing technique
- •Oocytes from patients older than 40 years
研究组 & 干预措施
Standard
Other
Standard thawing
干预措施: Thawing protocol (Other)
Fast
Other
Fast thawing
干预措施: thawing protocol (Other)
Ultrafast
Other
Ultrafast thawing
干预措施: thawing protocol (Other)
结局指标
主要结局
Oocytes Survival rate
时间窗: 2 hours post-warming
Oocyte survival rate will be assessed 2 hours after thawing using morphological evaluation under a light microscope. Surviving oocytes will be identified by the presence of an intact zona pellucida and oolemma, a round shape, and homogeneous cytoplasm without signs of lysis, fragmentation, or cytoplasmic granulation.
次要结局
- Chromosome distribution(2 hours post thawing)
- Spindle configuration(2 hours post thawing)
研究者
研究点 (2)
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