NCT00786292已完成不适用
Evaluation of Variable Pressure Support Ventilation in the Therapy of Acute Lung Injury (EVA-Trial)
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 试验地点
- 2
- 主要终点
- Effect on the arterial oxygenation
研究概览
简要总结
Variable pressure support during assisted spontaneous breathing (noisy PSV) has been shown to improve the respiratory function in experimental acute lung injury (ALI). We aimed at comparing the effects of noisy PSV with traditional PSV on the respiratory function of patients suffering from ALI.
研究设计
- 研究类型
- Interventional
- 主要目的
- Treatment
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age 18 to 75 yrs
- •150 mmHg < PaO2/FIO2 < 300 mmHg
- •mechanical ventilation with PSV or BIPAP
- •less than 15 days of mechanical ventilation
- •at least 20% of minute ventilation originated from spontaneous breathing
排除标准
- •BMI > 35
- •esophageal disease
- •neuromuscular disease
- •instable thorax
- •pneumothorax
- •head trauma
- •brain injury
- •increased intracranial pressure
- •agitation
- •increased need for vasoactive drugs
- •chronic lung disease
- •acute coronary disease
- •participation in another clinical trial within the last 4 weeks at enrollment
- •Interruption criteria:
- •acute change of mental status
- •SaO2 < 92%
- •pHa < 7.30
- •respiratory rate > 30 or < 6 /min
- •diaphragm/thorax antagonism
- •diaphoresis
- •abnormal use of respiratory muscles
- •increase of the heart rate above 120% of baseline or absolute value < 60 or > 130 /min
- •mean arterial pressure above 120% of baseline or absolute value < 70 or > 110 mmHg
结局指标
主要结局
Effect on the arterial oxygenation
次要结局
- Effect on the work of breathing
- Effect on PaCO2
研究者
PD Dr. Marcelo Gama de Abreu
Prof. Dr.
Technische Universität Dresden
研究点 (2)
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