Physiological Research on Variable Pressure Support Ventilation in Patients With Acute Acute Lung Injury: Part I and Part II
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Acute Lung Injury (ALI)
- Sponsor
- University of Genova
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Effect on arterial oxygenation in each setting of variability
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
Noisy Pressure Support Ventilation (noisy-PSV) would lead to improved lung function, while preserving respiratory muscle unloading. Basically, noisy PSV differs from other assisted mechanical ventilation modes that may also increase the variability of the respiratory pattern (e.g. proportional assist ventilation) by the fact that the variability does not depend on changes in the patient's inspiratory efforts.
The aim of this study is to evaluate the optimal variability for noisy PSV in patients with ALI based on its effects on respiratory mechanics, breathing comfort, gas exchange, and hemodynamics. The investigators hypothesize that noise in pressure support leads to variations in VT that are able to improve lung function and that physiologic variables respond differently to the degree of variability in pressure support
Investigators
Paolo Pelosi
Full Professor - Chair of Anesthesiology and Intensive Care Medicine. Chief of Intensive Care Medicine
University of Genova
Eligibility Criteria
Inclusion Criteria
- •Age ≥ 18 years
- •Intubated/tracheostomized patients in assisted mechanical ventilation
- •PaO2/FiO2 100-300, with PEEP ≥ than 5 cmH2O.
Exclusion Criteria
- •Pregnancy
- •History of chronic lung disease (COPD)
- •Presence of thoracic drainage
Outcomes
Primary Outcomes
Effect on arterial oxygenation in each setting of variability
Time Frame: after 45 minutes of mechanical ventilation with each level of variable pressure support
The investigators perform an arterial blood gas and oxygenation is evaluated with PaO2/FiO2 ratio
Secondary Outcomes
- effects on hemodynamic(after 45 minutes of mechanical ventilation with each level of variable pressure support)
- effect on arterial carbon dioxide(after 45 minutes of mechanical ventilation with each level of variable pressure support)
- work of breathing(every 9 minutes, up to 45 minutes, of mechanical ventilation in each level of variable pressure support)