Physiological Research on Variable Pressure Support Ventilation in Patients With Acute Acute Lung Injury: Part I and Part II
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Effect on arterial oxygenation in each setting of variability
研究概览
简要总结
Noisy Pressure Support Ventilation (noisy-PSV) would lead to improved lung function, while preserving respiratory muscle unloading. Basically, noisy PSV differs from other assisted mechanical ventilation modes that may also increase the variability of the respiratory pattern (e.g. proportional assist ventilation) by the fact that the variability does not depend on changes in the patient's inspiratory efforts.
The aim of this study is to evaluate the optimal variability for noisy PSV in patients with ALI based on its effects on respiratory mechanics, breathing comfort, gas exchange, and hemodynamics. The investigators hypothesize that noise in pressure support leads to variations in VT that are able to improve lung function and that physiologic variables respond differently to the degree of variability in pressure support
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years
- •Intubated/tracheostomized patients in assisted mechanical ventilation
- •PaO2/FiO2 100-300, with PEEP ≥ than 5 cmH2O.
排除标准
- •Pregnancy
- •History of chronic lung disease (COPD)
- •Presence of thoracic drainage
结局指标
主要结局
Effect on arterial oxygenation in each setting of variability
时间窗: after 45 minutes of mechanical ventilation with each level of variable pressure support
The investigators perform an arterial blood gas and oxygenation is evaluated with PaO2/FiO2 ratio
次要结局
- effects on hemodynamic(after 45 minutes of mechanical ventilation with each level of variable pressure support)
- effect on arterial carbon dioxide(after 45 minutes of mechanical ventilation with each level of variable pressure support)
- work of breathing(every 9 minutes, up to 45 minutes, of mechanical ventilation in each level of variable pressure support)
研究者
Paolo Pelosi
Full Professor - Chair of Anesthesiology and Intensive Care Medicine. Chief of Intensive Care Medicine
University of Genova