Evaluation of Variable Pressure Support Ventilation in the Therapy of Acute Lung Injury
Not Applicable
Completed
- Conditions
- Acute Lung Injury
- Registration Number
- NCT00786292
- Lead Sponsor
- Technische Universität Dresden
- Brief Summary
Variable pressure support during assisted spontaneous breathing (noisy PSV) has been shown to improve the respiratory function in experimental acute lung injury (ALI). We aimed at comparing the effects of noisy PSV with traditional PSV on the respiratory function of patients suffering from ALI.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- age 18 to 75 yrs
- 150 mmHg < PaO2/FIO2 < 300 mmHg
- mechanical ventilation with PSV or BIPAP
- less than 15 days of mechanical ventilation
- at least 20% of minute ventilation originated from spontaneous breathing
Exclusion Criteria
- BMI > 35
- esophageal disease
- neuromuscular disease
- instable thorax
- pneumothorax
- head trauma
- brain injury
- increased intracranial pressure
- agitation
- increased need for vasoactive drugs
- chronic lung disease
- acute coronary disease
- participation in another clinical trial within the last 4 weeks at enrollment
Interruption criteria:
- acute change of mental status
- SaO2 < 92%
- pHa < 7.30
- respiratory rate > 30 or < 6 /min
- dyspnea
- diaphragm/thorax antagonism
- diaphoresis
- abnormal use of respiratory muscles
- increase of the heart rate above 120% of baseline or absolute value < 60 or > 130 /min
- mean arterial pressure above 120% of baseline or absolute value < 70 or > 110 mmHg
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Effect on the arterial oxygenation
- Secondary Outcome Measures
Name Time Method Effect on the work of breathing Effect on PaCO2
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie improved respiratory function with noisy PSV in ALI patients?
How does variable pressure support ventilation compare to traditional PSV in ALI treatment outcomes?
Are there specific biomarkers that predict response to noisy PSV in acute lung injury?
What adverse events are associated with noisy PSV in ALI patients and how are they managed?
What combination therapies or alternative ventilation strategies compete with noisy PSV for ALI treatment?
Trial Locations
- Locations (1)
University Clinic Carl Gustav Carus, Technical University Dresden
🇩🇪Dresden, Germany
University Clinic Carl Gustav Carus, Technical University Dresden🇩🇪Dresden, Germany