NCT01819571已完成不适用
Pulse Pressure Variation for Prediction of Fluid Responsiveness in Coronary Artery Disease Patients With Diastolic Dysfunction
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- predictability of pulse pressure variation (PPV) on fluid responsiveness in patients with coronary disease who have normal diastolic function and diastolic dysfunction.
研究概览
简要总结
The investigators hypothesized that predictability of pulse pressure variation (PPV) on fluid responsiveness would be reduced in patients with coronary disease who have diastolic dysfunction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients older than 20 years
- •scheduled for elective coronary artery bypass grafting
- •normal diastolic function (E/E' < 8) or diastolic dysfunction (E/E' >15) according to preoperative Echocardiographic evaluation
排除标准
- •arrythmia,
- •reduced left ventricular function (ejection fraction < 40%)
- •valvular heart disease requiring concomitant surgical correction
- •pulmonary hypertension (mean pulmonary arterial pressure ≥30 mm Hg)
- •peripheral arterial occlusive disease, pulmonary disease (asthma, chronic obstructive pulmonary disease, and lung resection)
- •end-stage renal disease
研究组 & 干预措施
Normal diastolic function group
Experimental
干预措施: Fluid loading (Voluven) (Drug)
Diastolic dysfunction group
Active Comparator
干预措施: Fluid loading (Voluven) (Drug)
结局指标
主要结局
predictability of pulse pressure variation (PPV) on fluid responsiveness in patients with coronary disease who have normal diastolic function and diastolic dysfunction.
时间窗: 10 minutes after fluid replacement
After induction of anesthesia and applying mechanical ventilation, hemodynamic parameters (including PPV measured by Philips IntelliVue MP 70®) were recorded
次要结局
未报告次要终点
研究者
研究点 (1)
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