Protective ventilation during general anesthesia for abdominal surgery * a randomized controlled trial - PROVHILO

Academisch Medisch Centrum0 个研究点目标入组 100 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•- Planned elective abdominal surgery
•- General anesthesia with intravenous medication
•- High or intermediate risk for postoperative pulmonary complications (ARISCAT risk score * 26)

•- Age < 18 years
•- Body mass index > 40 kg/m2
•- Laparoscopic surgery
•- Previous lung surgery (any)
•- Persistent hemodynamic instability, intractable shock (considered hemodynamic unsuitable for the study by the patient*s managing physician)
•- History of previous severe chronic obstructive pulmonary disease, COPD (non*invasive ventilation and/or oxygen therapy at home or repeated systemic corticosteroid therapy for acute exacerbations of COPD)
•- Recent immunosuppressive medication (patients receiving chemotherapy or radiation therapy, within the last 2 months)
•- Severe cardiac disease (New York Heart Association class III or IV, or acute coronary syndrome, or persistent ventricular tachyarrhythmia*s)
•- Mechanical ventilation > than 30 minutes within last 30 days
•(e.g., in cases of general anesthesia because of surgery)
•- Pregnancy (excluded by laboratory analysis)
•- Acute lung injury or acute respiratory distress syndrome expected to require prolonged postoperative mechanical ventilation
•- Neuromuscular disease (any)
•- Consented for another interventional study or refusal to participate in the study

发起方