KCT0006650尚未招募未知
Cohort study for management of patients with early-onset dementia
适应症
试验速览
- 阶段
- 未知
- 状态
- 尚未招募
- 入组人数
- 400
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational Study
入排标准
- 年龄范围
- 19?(Year) 至 o Limit（—）
- 性别
- All
入选标准
- •? Early onset AD
- •? Onset age between 19-64 years
- •? Meets DSM-V criteria for Dementia (American Psychiatric Association. 2013)
- •? Meets NIA-AA criteria for Probable AD dementia (McKhann et al., 2011)
- •? Amyloid positive status (PET scan) or A+T+N+ status based on CSF AD biomarkers
- •? Must have a caregiver who can provide information about the participant’s cognitive and functional performance
- •? Willing and able to consent to the protocol
- •? Early onset MCI
- •? Onset age between 19-64 years
- •? Memory or cognitive functions complaint, preferably corroborated by an informant
- •? Preserved activities of daily living
- •? Not demented
- •? Amyloid positive status (PET scan) or A+T+N+ status based on CSF AD biomarkers
- •? Must have a caregiver who can provide information about the participant’s cognitive and functional performance
- •? Willing and able to consent to the protocol
- •? Early SCD
- •? Onset age between 19-64 years
- •? Subjective cognitive impairment
- •? Meets criteria for cognitively normal, based on neuropsychological test
- •? Amyloid positive status (PET scan) or A+T+N+ status based on CSF AD biomarkers
- •? Willing and able to consent to the protocol
- •? Onset age between 19-64 years
- •? Meets criteria for bvFTD (Rascovsky et al., 2011)
- •? Meets criteria for svPPA (Gorno-Tempini et al., 2011)
- •? Meets criteria for nfvPPA (Gorno-Tempini et al., 2011)
- •? Meets El Escorial criteria for MND combined with FTD
- •? Must have a caregiver who can provide information about the participant’s cognitive and functional performance
- •? Willing and able to consent to the protocol
- •? Other EOD
- •? Onset age between 19-64 years
- •? Leukodystrophy
- •? Early onset neurodegenerative dementia other than FTD or EOAD
- •? Other unspecified EOD
- •? Must have a caregiver who can provide information about the participant’s cognitive and functional performance
- •? Willing and able to consent to the protocol
- •# Family Members
- •? Family members whose patient has known pathogenic mutations, two or more first degree family members with EOD, or one or more family member with EOD for 3 generations
- •? Willing and able to consent to the protocol
排除标准
- •? History of major psychiatric disorders (schizophrenia, major depression, bipolar disorders, alcohol/substance abuse, delirium, etc.)
- •? History of cerebral infarction, cerebral hemorrhage, brain tumor or systemic disease which could affect cognitive functions
- •? Contraindications to MRI or CT (e.g., claustrophobia, pacemaker, select aneurismal clip, metal fragments, or ventriculoperitoneal shunt, etc.)
- •? Illiteracy
- •? Previous enrollment in a therapeutic trial
- •? Pregnant or lactating
- •? Deemed ineligible by the site PI for any other reason
研究者
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