Assessment of Seminal Levels of Cystatin C and Endoglin in Infertile Men With Varicocele
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- The Quality of Semen
研究概览
简要总结
Varicocele is a major contributor in male infertility. The improvement of sperm parameters after varicocelectomy supports this contribution. The pathophysiological mechanisms of varicocele-induced male infertility are still under investigation. Cystatin C (Cys C) and endoglin are secreted glycoproteins that recently linked to several cellular changes common in varicocele like apoptosis and autophagy.
详细描述
Subinguinal varicocelectomy under general anesthesia and complete aseptic condition was done to infertile men with varicocele
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 39 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Infertile men
- •Varicocele
- •Poor sperm parameters
排除标准
- •Men with systemic diseases
- •Infertile men due to other causes than varicocele
结局指标
主要结局
The Quality of Semen
时间窗: 6 months
According to WHO 2010 guidelines regarding semen analysis * Sperm concentration (to be more than 15 million sperm per milliliter). * Sperm motility (not less than 60% progressive motility). * Sperm morphology (not less than 6% normal morphology).
次要结局
未报告次要终点
研究者
Essam Mohamed El-sayed Akl
Assistant Professor
Benha University