Impact of Home and Clinical Blood Pressure Variability on Arteriosclerosis and Metabolic Indicators
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 4,188
- 试验地点
- 2
- 主要终点
- Correlation between Home Blood Pressure Variability and Pulse Wave Velocity
研究概览
简要总结
This observational study investigates the correlation between home blood pressure variability (BPV) and arteriosclerosis, alongside metabolic indicators, in hypertensive patients over a three-year period. The research specifically focuses on the predictive value of home BPV for major adverse cardiovascular events (MACE) including myocardial infarction, stroke, and heart failure hospitalizations. Utilizing a mobile application called Healthscan for daily BP monitoring, the study aims to enhance the understanding of how BPV impacts cardiovascular and metabolic health in a real-world setting.
详细描述
Objective:
This longitudinal, non-randomized study aims to explore the prognostic value of home-measured blood pressure variability (BPV) in predicting arteriosclerosis and metabolic dysfunction in patients with hypertension. By examining the relationship between home BPV and several vascular and metabolic health indicators, this study seeks to validate home BP monitoring as a crucial component of hypertension management.
Study Design:
Participants will be recruited from multiple clinical settings and followed for a three-year period, during which they will use the Healthscan mobile application to record their daily blood pressure readings. The primary outcome measure is the correlation between home BPV and pulse wave velocity, a key marker of arteriosclerosis. Secondary outcomes include other arteriosclerosis indicators such as ankle-brachial index and central systolic blood pressure, as well as metabolic indicators like fasting glucose and lipid profiles.
Methodology:
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults aged 19 years or older.
- •Diagnosed with hypertension.
- •Regular use of antihypertensive medication for at least two years.
- •Access to a home blood pressure monitor.
- •Comprehensive medical records available for the past year.
排除标准
- •Participants who are unable to consent or who might not reliably use the home monitoring app.
结局指标
主要结局
Correlation between Home Blood Pressure Variability and Pulse Wave Velocity
时间窗: 1 year
Measure the strength and nature of the relationship between variability in home-monitored blood pressure and pulse wave velocity, a primary indicator of arteriosclerosis.
次要结局
- Association between Home BPV and Additional Arteriosclerosis Indicators(1 year)
- Correlation between Home BPV and Metabolic Indicators(1 year)
研究者
Hyung Joon Joo
Professor
Korea University Anam Hospital