Features of Chronic Obstructive Pulmonary Disease Clinical Course in Obese Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 176
- 试验地点
- 1
- 主要终点
- Simptoms
研究概览
简要总结
The study included 176 patients with COPD. The first group included 88 normal weight patients with COPD: 71 men and 17 women, mean age 62.40 ± 8.83 years. The second group included 88 patients with COPD and obesity: 64 men and 24 women, mean age 62.94 ± 5.96 years. We assessed the frequency of COPD exacerbations in last 12 months, the severity of symptoms such as dyspnea, sputum production, fatigue. Spirometry, six-minute walk test and analysis of body tissue type composition were performed. BODE index was calculated. Levels of leptin, adiponectin, interleukins-4,6,8,10, interferon-γ, c-reactive protein (CRP), tumor necrosis factor receptor 1 (TNF-R1), tumor necrosis factor receptor 2 (TNF-R2), tumor necrosis factor alpha (TNF-α) were measured in blood serum.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •COPD diagnosis, informed consent for voluntary participation in the study
排除标准
- •patient participation in any interventional study,
- •COPD exacerbation,
- •concomitant lung diseases, such as confirmed or suspected malignant lung disease or other respiratory disease, such as interstitial pulmonary fibrosis, tuberculosis, sarcoidosis, bronchial asthma, bronchiectasis,
- •concomitant diseases of other organs and systems, such as acute cardiovascular diseases, chronic kidney diseases and liver failure.
结局指标
主要结局
Simptoms
时间窗: 1 year
dyspnea, sputum production and fatigue
Labotary tests
时间窗: 1 year
Levels of adiponectin (µg / ml) measured in blood serum
Spirometry
时间窗: 1 year
FEV1, % pred,FVC, % pred.,FEV1/FVC, %
次要结局
- Symptroms and laboratory correlations(1 year)