EARLY Microvascular Dysfunction Prediction Using Quantitative Flow Ratio in ST-segment Elevation MYOcardial Infarction Patients With Pharmaco-Invasive Strategy (EARLY-MYO-QFR PI)
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Cardiac magnetic resonance (CMR)
研究概览
简要总结
The study intends to provide important data on whether the noval method using quantitative flow ratio could predict microvascular dysfunction.
详细描述
Microvascular dysfunction (MVD) is a serious complication of PCI, which happens frequently after STEMI and always correlates with a poor prognosis. However, precise and simplified assessment of MVD is difficult, especially in the acute phase of STEMI patients. Resent studies suggested that FFR could be overestimated when MVD exists. But whether the overestimated value of FFR caused by CMR defined MVO could reflect microcirculation function is still unclear.
This study is a retrospective study using STEMI patients who underwent pharmaco-invasive strategy as the population. Contrast-enhanced CMR was performed 5 days after PCI as the reference standard.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •STEMI patients treated with revasculation within 12 hours from onset of symptoms to PCI time and received CMR 5 days afterwards. STEMI was defined as a combination of the following: chest pain for more than 30min, electrocardiographic (ECG) changing with ST segment elevation of >2 mm in at least 2 precordial leads and >1 mm in limb leads, and abnormal troponin levels or CKMB levels higher than twice the upper limit of normal.
- •Patients underwent successfully pharmaco-invasive strategy with half-dose alteplase.
排除标准
- •Patients with left bundle branch block in the presenting ECG, cardiogenic shock, PCI or bypass surgery history.
- •Patients with residual stenosis <50%.
- •Patients with unqualified coronary angiographic images with problems such as ostial lesion, severe vessel tortuosity and diffuse long lesions.
结局指标
主要结局
Cardiac magnetic resonance (CMR)
时间窗: Five days after PCI
Cardiac magnetic resonance (CMR) is a non-invasive test for MVO assessing
次要结局
- TIMI Flow Grade (TFG)(One mins after PCI)
- TIMI Myocardial Perfusion Grade (TMPG)(One mins after PCI)