The effects of intrathecal neostigmine added to bupivacaine on postoperative analgesic requirement in Patients undergoing lower limb orthopedic surgery

Patients receiving neostigmine had a significantly prolonged duration of motor block compared to the control group. The difference of the mean time to the first analgesic request was also significantly longer in neostigmine group The total analgesic consumption during the first 12 hours after surgery was devoid of any significant difference between groups N and C .The two groups were not significantly different in terms of intraoperative and postoperative side effects.