Investigation of the Effects of Aerobic Exercise, Balance Exercise and Combined Exercise Practices on Frailty, Balance, Fall Risk, Reaction Time, Cognitive Functions and Quality of Life in Dementia Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 33
- 试验地点
- 2
- 主要终点
- Muscle Strength Assessment for Sarcopenia
研究概览
简要总结
Dementia is a clinical disorder characterized by progressive and permanent loss of multiple cognitive functions, especially memory, at a level that affects activities of daily living. There is no pharmacologic treatment method that can change the prognosis in dementia. The methods used today are symptomatic and cause various side effects. For this reason, non-pharmacologic approaches are on the agenda in the treatment of dementia. Among these approaches, physical activity approaches such as symptomatic treatment or exercise come to the forefront due to their prognosis-slowing effects. There are also many studies showing that dementia is directly related to physical performance and frailty. Deterioration of physical performance, increased frailty, and decreased muscle strength create a vicious circle with the prognosis of dementia. In addition, patients with dementia have balance problems due to prolonged reaction time, cognitive impairment and physical problems, and the risk of falls increases. In order to prevent the risk of falls, exercise practices are of great importance. Although the effects of aerobic exercise on dementia have been examined many times in the literature, there are very few studies examining the effects of balance exercises and combined exercises. In addition, physical characteristics such as frailty and muscle weakness, which are very common in patients with dementia, have not been evaluated as a whole in studies on patients with dementia. Therefore, this study will be conducted to comparatively examine the effects of combined aerobic exercise and balance exercises on balance and falls, frailty, muscle strength, cognitive functions, and reaction time in patients with dementia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 90 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age over 65 years,
- •To be able to speak and understand Turkish,
- •To have at least primary education,
- •Perceive and adapt to simple commands,
- •Scoring between 18-23 on the standardized mini mental state assessment scale (200),
- •To be able to provide independent mobilization,
- •Volunteering to participate.
排除标准
- •Rapid progression of dementia (infectious, vascular, hematologic diseases),
- •Cardiac or cerebrovascular event, endocrine disorder, fluid-electrolyte imbalance or infection during the follow-up period,
- •Presence of malignancy,
- •Detection of a delirium picture,
- •Presence of severe depression,
- •Participate in a regular exercise program for at least 6 months before the study,
- •Having a fracture or fracture surgery in the lower extremity within the last year,
- •Any orthopedic problem that prevents him/her from exercising.
结局指标
主要结局
Muscle Strength Assessment for Sarcopenia
时间窗: Change from Baseline Muscle Strength Assessment for Sarcopenia at 6 weeks
Muscle strength measurement in kg with a dynamometer
Single Leg Stance Test
时间窗: Change from Baseline Single Leg Stance Test at 6 weeks
If unable to stand for 5 seconds or less client at greater risk of injury from fall.
Functional Reach Test
时间窗: Change from Baseline Functional Reach Test at 6 weeks
10"/25 cm or greater Low risk of falls; 6"/15cm to 10"/25cm Risk of falling is 2x greater than normal; 6"/15cm or less Risk of falling is 4x greater than normal; Unwilling to reach Risk of falling is 8x greater than normal.
30 Seconds Sit To Stand Test
时间窗: Change from Baseline 30 Seconds Sit To Stand Test at 6 weeks
For testing leg strength and endurance in older adults. The score is the total number of stands within 30 seconds.
Reaction Time Test
时间窗: Change from Baseline at 6 weeks
The 3 reaction times recorded in milliseconds are averaged.
Wechsler Memory Scale
时间窗: Change from Baseline Wechsler Memory Scale at 6 weeks
Scored on 1-19 Scaled Score Metric. High scores (13 and above) indicate better than expected performance on the dependent variable given performance on the control variable. Low scores (7 and below) indicate poorer than expected performance on the dependent score given performance on the control score. Scores in the average range (8-12) indicate no difference in performance between the control and dependent measures.
Edmonton Frailty Scale
时间窗: Change from Baseline Edmonton Frailty Scale at 6 weeks
0 - 5 = Not Frail, 6 - 7 = Vulnerable, 8 - 9 = Mild Frailty, 10-11 = Moderate Frailty, 12-17 = Severe Frailty
Mental Rotation Test
时间窗: Change from Baseline Mental Rotation Test at 6 weeks
Contains 20 pairs of items worth 1 point each. A high score indicates good mental rotation skill.
Tinetti Balance and Gait Assessment
时间窗: Change from Baseline Tinetti Balance and Gait Assessment at 6 weeks
The Tinetti test has a gait score and a balance score. It uses a 3-point ordinal scale of 0, 1 and 2. Gait is scored over 12 and balance is scored over 16 totalling 28. The lower the score on the Tinetti test, the higher the risk of falling.
Dynamic Gait Index
时间窗: Change from Baseline Dynamic Gait Index at 6 weeks
Each item is scored on a scale of 0 to 3, with 3 indicating normal performance and 0 representing severe impairment. The best possible score on the Dynamic Gait Index is a 24.
Johns Hopkins Fall Risk Assessment Tool
时间窗: Change from Baseline Johns Hopkins Fall Risk Assessment Tool at 6 weeks
6-13 Total Points = Moderate Fall Risk, \>13 Total Points = High Fall Risk
Geriatric Depression Scale
时间窗: Change from Baseline Geriatric Depression Scale at 6 weeks
There are 15 questions. Each question is worth 1 point. A score of 5 or more suggests depression.
Mini Mental State Examination
时间窗: Change from Baseline Reaction Time Test at 6 weeks
The maximum score for the Mini Mental State Examination is 30. A score of 25 or higher is classed as normal. If the score is below 24, the result is usually considered to be abnormal, indicating possible cognitive impairment.
The World Health Organization Quality of Life - Old Module
时间窗: Change from Baseline The World Health Organization Quality of Life - Old Module at 6 weeks
It is scored in the range of 4-20. The higher the score, the better the quality of life.
Spatial Orientation Test
时间窗: Change from Baseline Spatial Orientation Test at 6 weeks
Contains 20 pairs of items worth 1 point each. A high score indicates good spatial orientation skill.
次要结局
未报告次要终点
研究者
Ilkem Guzel
Lecturer
Yuksek Ihtisas University