Connectomics in Psychiatric Classification
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Magnetic Resonance Imaging (MRI) Brain Imaging
研究概览
简要总结
Washington University Early Recognition Center is conducting a research study to examine brain functional connectivity and network patterns in participants with dementia.
详细描述
This study extends the assessment of brain connectivity and function, being conducted in the Human Connectome Project (HCP), to psychiatrically ill populations. The HCP consortium has made significant improvements in MRI instrumentation, data acquisition, preprocessing, and analysis. These improvements are currently providing publicly available data on the structure, function, and connectivity of young adult human (age 22-35) brains at unprecedented spatial resolution, temporal resolution, and accuracy. This study will focus on individuals aged 45-85 years who have a diagnosis of dementia, or are healthy controls. Additionally, similar to the HCP, the investigator will study the effect of genetics on the patterns of brain connectivity in various psychiatric populations. DNA will be collected non-invasively from saliva. Furthermore, this investigator will study cortisol levels in hair samples as an additional assessment to help characterize brain imagining findings.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 45 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Ages 45-85
- •Has consented to participate or has an LAR present that has consented to participate
- •DSM-5 diagnosis of Dementia
排除标准
- •Any genetic disorder, such as cystic fibrosis or sickle cell disease
- •Multiple Sclerosis
- •Cerebral Palsy
- •Loss of consciousness for >30 minutes
- •Pregnancy
- •Hospitalization for stroke, brain aneurysm, brain hemorrhage, or subdural hematoma
结局指标
主要结局
Magnetic Resonance Imaging (MRI) Brain Imaging
时间窗: within one month of study enrollment
The current project aims to uncover latent, homogenous, connectivity phenotypes using neuroimaging tools, which are free from the limitations of traditional diagnostic boundaries, and which correlate with clinical characteristics. The investigator will use resting state functional connectivity MRI (rs-fcMRI), diffusion MRI (dMRI) and tract-based spatial statistics (TBSS) to identify brain signatures that cut across psychiatric disorders.
次要结局
- DNA testing through saliva(within one month of study enrollment)