试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 主要终点
- Plasma GnRH levels resulting from hypothalamus activation via LC-MS
研究概览
简要总结
This study is investigating brain regions that share functional connectivity with the hypothalamus and the stimulation of those regions using repetitive transcranial magnetic stimulation (rTMS) to activate the hypothalamus indirectly. The goal of this study is to determine the effectiveness of rTMS in influencing the hypothalamus to better understand the mechanisms between it and the neuroendocrine processes it controls.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age: 21-55
- •Gender: Females and Males
- •Weight: Less than 280 pounds
- •Normal vision with corrective lenses if necessary
- •Fluent in English (written and spoken)
排除标准
- •History of epilepsy/seizures (including history of withdrawal/provoked seizures)
- •Metal implant in brains (e.g. deep stimulation), cardiac pacemaker, or cochlear implants
- •Shrapnel or any ferromagnetic item in the head
- •Showing symptoms of withdrawal from alcohol or benzodiazepines
- •Current severe insomnia (must sleep a minimum of 4 hours the night before stimulation)
- •Migraine or significant headaches
- •Shoulder or neck stiffness
- •Over 280 pounds
- •In-dwelling ferrous metals
- •Left handed
- •Abnormal hearing
- •Abnormal vision that cannot be corrected with lenses
- •Claustrophobia
- •Illicit drug use
- •Psychotropic medication use
- •Marijuana and/or nicotine use
- •Psychiatric or neurological conditions
- •Endocrine conditions
- •History of head trauma with loss of consciousness
结局指标
主要结局
Plasma GnRH levels resulting from hypothalamus activation via LC-MS
时间窗: 3 hours
Measure levels of the gonadotropin-releasing hormone (GnRH) in blood plasma through liquid chromatography-mass spectrometry (LC-MS) resulting from hypothalamus and neuroendocrine activation
Plasma oxytocin levels via LC-MS
时间窗: 3 hours
Measure levels of the oxytocin hormone in blood plasma through liquid chromatography-mass spectrometry (LC-MS) resulting from hypothalamus and neuroendocrine activation
Plasma vasopressin levels via LC-MS
时间窗: 3 hours
Measure levels of the vasopressin hormone in blood plasma through liquid chromatography-mass spectrometry (LC-MS) resulting from hypothalamus and neuroendocrine activation
Plasma TRH levels via LC-MS
时间窗: 3 hours
Measure levels of the thyrotropin-releasing hormone (TRH) in blood plasma through liquid chromatography-mass spectrometry (LC-MS) resulting from hypothalamus and neuroendocrine activation
Plasma ACTH levels via LC-MS
时间窗: 3 hours
Measure levels of the adrenocorticotropic hormone (ACTH) in blood plasma through liquid chromatography-mass spectrometry (LC-MS) resulting from hypothalamus and neuroendocrine activation
Plasma CRH levels via LC-MS
时间窗: 3 hours
Measure levels of the corticotropin-releasing hormone (CRH) in blood plasma through liquid chromatography-mass spectrometry (LC-MS) resulting from hypothalamus and neuroendocrine activation
Plasma somatostatin levels via LC-MS
时间窗: 3 hours
Measure levels of the somatostatin hormone, or growth hormone-inhibiting hormone (GHIH) in blood plasma through liquid chromatography-mass spectrometry (LC-MS) resulting from hypothalamus and neuroendocrine activation
Plasma FSH levels via LC-MS
时间窗: 3 hours
Measure levels of the follicle-stimulating hormone (FSH) in blood plasma through liquid chromatography-mass spectrometry (LC-MS) resulting from hypothalamus and neuroendocrine activation
Plasma cortisol levels via LC-MS
时间窗: 3 hours
Measure levels of the cortisol hormone in blood plasma through liquid chromatography-mass spectrometry (LC-MS) resulting from hypothalamus and neuroendocrine activation
Plasma PRLH levels via LC-MS
时间窗: 3 hours
Measure levels of the prolactin-releasing hormone (PRLH) in blood plasma through liquid chromatography-mass spectrometry (LC-MS) resulting from hypothalamus and neuroendocrine activation
Plasma LH levels via LC-MS
时间窗: 3 hours
Measure levels of the luteinizing hormone (LH) in blood plasma through liquid chromatography-mass spectrometry (LC-MS) resulting from hypothalamus and neuroendocrine activation
次要结局
- Heart rate via pulse oximeter(3 hours)
- Blood pressure via sphygmomanometer(3 hours)