Crossover Meal Study Investigating Effects of Advanced Glycation Endproducts on Satiety and Inflammation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 19
- 试验地点
- 2
- 主要终点
- Appetite sensation
研究概览
简要总结
The purpose of the meal study is to investigate acute effects on satiety and inflammation of advanced glycation endproducts (AGE) in healthy overweight subjects. The AGE content of the meal is affected by food preparation methods: frying/grilling versus boiling/steaming.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy males and females between 20 and 50 years old
- •BMI 25-40
- •Waist circumference above 88 cm for women and above 102 cm for men
排除标准
- •Exercise training above 8 hour/week
- •Pregnant or breast-feeding women
- •Post-menstrual women
- •Regular use of medicine (except contraceptive pills)
- •Previous gastric bypass surgery
- •Donation of blood within the last 3 months
- •Involvement in other clinical trials
- •Allergic to paraaminobenzoic acid
结局指标
主要结局
Appetite sensation
时间窗: Every 30 min up to 5 hours after test meal
Appetite sensation measured by visual analogue scales
Plasma ghrelin
时间窗: Continuous measurement up to 5 hours after test meal
Plasma GLP-1
时间窗: Continuous measurements up to 5 hours after test meal
Plasma PYY
时间窗: Continuous measurements up to 5 hours after test meal
Plasma insulin
时间窗: Continuous measurements up to 5 hours after test meal
Plasma glucose
时间窗: Continuous measurements up to 5 hours after test meal
Urine AGE
时间窗: From 24 hour before to 48 hour after test meal
次要结局
- MIF(Continuous measurements up to 5 hours after test meal)
- Expression of genes related to AGE(Continuous measurements up to 24 hours after test meal)
- Plasma triglycerides(Continuous measurements up to 5 hours after test meal)
- IL-1 beta(Continuous measurements up to 5 hours after test meal)
- IL-6(Continuous measurements up to 5 hours after test meal)
- TNF-alpha(Continuous measurements up to 5 hours after test meal)
- CRP(Continuous measurements up to 5 hours after test meal)
- VCAM(Continuous measurements up to 5 hours after test meal)
- ICAM(Continuous measurements up to 5 hours after test meal)
- Plasma AGE(Continuous measurements up to 48 hours after test meal)
- Urine isoprostanes(From 24 hour before to 24 hours after test meal)
研究者
AAstrup
Dr Med Sci
University of Copenhagen