Myocardial Oedema in ST Segment Elevation Myocardial Infarction Myocardial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- The mass of myocardial oedema measured by CMR
研究概览
简要总结
Cardiac magnetic resonance imaging (CMR) is a non invasive technique used to obtain functional and anatomical information on the heart. Several CMR parameters measured after primary percutaneous coronary intervention (PPCI) have been shown to have prognostic value and are increasingly being used as surrogate endpoints in clinical trials. Myocardial oedema is a prognostic indicator following myocardial infarction1. Myocardial salvage is calculated as the myocardial oedema minus infarct size; this again is a prognostic indicator following STEMI. However, myocardial oedema imaging is controversial. There are multiple sequences available, with no standardisation of sequences used to assess this surrogate endpoint. The investigators propose to conduct a study to measure the myocardial oedema by all available techniques to determine the agreement between these methods.
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •providing written informed consent
排除标准
- •contraindication to CMR,
- •atrial fibrillation,
- •claustrophobia,
- •eGFR < 30
结局指标
主要结局
The mass of myocardial oedema measured by CMR
时间窗: Day 2 following STEMI
次要结局
- Extra cellular volume(Day 2 following STEMI)
研究者
Elisa McAlindon
principle investigator
University of Bristol
