The Interaction Between Resting Metabolic Rate, Physical Activity and Thyroid Hormone in Females
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 42
- 试验地点
- 1
- 主要终点
- Fat mass
研究概览
简要总结
This Study is focused on the interaction between resting metabolic rate (RMR), physical activity (PA), and thyroid hormones (TH). TH controls almost all the cell activities of the body so, it is known as one of the major regulatory hormones. This is the reason for individuals who suffer from thyroid disorders show abnormal metabolism. Recently it was suggested that interindividual variations in thyroid hormone levels also influence daily physical activity.
详细描述
In this study, investigators will recruit adult females with a BMI ≥18.5. After the screening process, eligible volunteers will undergo certain measurements including body composition, resting metabolism daily physical activity, thyroid hormone levels, and total energy expenditure. The investigators will access the changes in resting metabolism and daily physical activities with the differences in thyroid hormone levels.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Female age ≥18;
排除标准
- •Intended weight change exceeding 2kg within the past three months;
- •Having any special medical diets or having eating disorders;
- •Pregnant women or breastfeeding women;
- •People who have metal implants in their bodies;
- •Patients with metabolic diseases, infectious diseases, and genetic disorders such as hypothyroidism, and hyperthyroidism;
- •Patients with a personal or family history of medullary thyroid carcinoma (MTC), or patients with rare type 2 multiple endocrine tumor syndrome (MEN2); People with a fear of needles (Trypanophobia), claustrophobia; People who are fear of blood (Hemophobia) or pathological hypotension;
结局指标
主要结局
Fat mass
时间窗: Measurements will take at the first day of the visit
Fat mass will be measured by Magnetic Resonance Imaging (Shanghai united imaging, uMR 790 ) or DXA (Hologic).
Far free mass
时间窗: Measurements will take at the first day of the visit
Fat free mass will be measured by Bioimpedance Analysis (Tanita, MC-980) or DXA (Hologic).
Height
时间窗: Measurements will take at the first day of the visit
Measured by seca 217 stable stadiometer. Subjects wearing no shoes.
Waist and Hip circumferences
时间窗: Measurements will take at the first day of the visit
Waist and Hip circumferences will be measured using a whole body laser scanner.
Bone mass
时间窗: Measurements will take at the first day of the visit
Bone mass will be measured by DXA (Hologic).
Body weight
时间窗: Measurements will take at the first day of the visit
Subjects will be asked to fast overnight and weight will be measured using a calibrated Seca body weight scale first thing in the morning on subjects wearing light clothes and no shoes.
Resting Metabolism
时间窗: measurements will take at the first day of visit
The whole room calorimeter/metabolic chamber (OMNICAL, Maastricht instrument) will be used to measure resting metabolic rate. The metabolic chamber is a sealed room with a continuous gas supply (CO2- 0.80×10-2, O2 -18.00×10-2), providing subjects with 24-hour energy expenditure data. The total energy expenditure of the subjects in MJ/day was plotted against time in 30-minute intervals over 24 hours. The lowest and most stable energy expenditure during sleep time was considered the RMR of the subjects, which occurred from 2:00 am to 5:00 am.
Physical activity
时间窗: Measurements last for 14 days
Physical activity of the participants will be recorded using GT3X accelerometer worn near the hip for a consecutive period of 14 days. The monitor should not be worn while bathing or swimming. The first day is discarded along with any day where the wear time is less than 10 hours. For a valid measure, the goal is to get at least 2 weekday and 2 weekend days.
Thyroid hormone
时间窗: Blood samples will collect at the first day of the visit.
Nurses will collect the blood samples on day 1. Levels of circulating thyroid hormones will be measured using radio immunoassay.
次要结局
- Total energy expenditure(Measurements take at the first day of the visit)
研究者
John R. Speakman
Professor, chief researcher
Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences