Split-Side Comparative Clinical Study of Platelet-Rich Fibrin Versus Platelet-Rich Plasma With or Without Microneedling in Treatment of Striae Distensae
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- INA score (Change in striae severity)
研究概览
简要总结
A split-side comparative clinical study evaluating the efficacy and safety of injectable platelet-rich fibrin (PRF) versus platelet-rich plasma (PRP), alone or combined with microneedling, in the treatment of striae distensae. Thirty patients received PRF or PRP on one side and combination therapy with microneedling on the contralateral side over five sessions. Outcomes included striae width, length, severity score, and patient satisfaction
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults ≥18 years
- •Presence of striae distensae (rubrae or alba)
- •Willingness to participate and provide informed consent
排除标准
- •Keloid or hypertrophic scar tendency
- •Bleeding disorders or anticoagulant use
- •Pregnancy
- •Active skin infections (e.g., herpes, impetigo, tinea)
- •History of malignancy or collagen disease
- •Use of antineoplastic drugs
- •Conditions impairing wound healing
- •Unrealistic expectations
研究组 & 干预措施
PRF
Intradermal injection of platelet-rich fibrin
干预措施: PRF group (Biological)
PRP
Intradermal injection of platelet-rich plasma
干预措施: PRP injection (Biological)
结局指标
主要结局
INA score (Change in striae severity)
时间窗: baseline to 1 month after last session
Change in striae severity (INA score)
时间窗: 1 month after last session
次要结局
未报告次要终点
研究者
Mona El Radi Kamal Mohamed Emam
Dr
Zagazig University