Taste Acuity and Caloric Intake After Acute Morphine Administration
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 36
- 试验地点
- 2
- 主要终点
- Taste
研究概览
简要总结
This study will investigate the effects of acute morphine administration on taste acuity and how much a person eats. It is hypothesized that there will be a dose dependent decrease in taste acuity and dose dependent increase in food intake associated with acute morphine administration. Knowledge from this study will impact the future of feeding behavior and obesity research in the general population. Results will also promote exploration of the long-term effect of opioid abuse on taste acuity and feeding behavior in substance abusing populations.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy adult male and female volunteers
- •Ages of 18 to 65
排除标准
- •History of drug dependence (including opioid use disorders)
- •History of taste dysfunction
- •Significant medical or Axis I psychiatric disorder
- •Any trauma or surgical procedures to the head or neck region
- •Medication or illicit drug more than 4 out of the last 30 days.
- •Pregnancy
- •Abnormal electrocardiogram findings
- •Negative rating of greater than 40% of the foods available for consumption
结局指标
主要结局
Taste
时间窗: 3 hours after dose administration
The primary outcome variable will be the taste acuity profile, which includes the taste detection threshold, recognition threshold, magnitude estimation, and hedonic response.
次要结局
- Calories(6 hours after dose administration)
研究者
Denis Antoine
Instructor
Johns Hopkins University