Mortality in Cancer Patients Admitted to the Intensive Care Unit in a Resource-limited Setting: A Prospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 142
- 试验地点
- 1
- 主要终点
- Mortality at 30 days
研究概览
简要总结
The purpose of this study is to determine 30 day mortality in cancer patients admitted to the intensive care unit in a resource limited setting.
详细描述
The management of cancer patients in the intensive care unit (ICU) has changed dramatically during the last two decades. Initial experiences showed high rates of hospital mortality, reaching up to 75-85% in patients requiring life-sustaining treatments, particularly mechanical ventilation. An increasing number of clinical experiences has been reported pointing to a significant improvement in survival of these patients. However, it is not clear if this results are generalizable to settings with resource constraints. Therefore, the purpose of this study is to determine 30 day mortality in cancer patients admitted to the intensive care unit in a resource limited setting.
This study is a prospective cohort of cancer patients admitted to the ICU in which the investigators will evaluate the prognostic of cancer patients admitted for a ICU trial or treatment in ICU without limitations. This study will not consider any change in the treatment plan of the patients. The source of the data will be the clinical records of the patients during the admission and the records of the cancer unit. There will be no direct contact of the research team with the patients or their family.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18 years-old or older
- •Histological diagnosis or high clinical suspicious of cancer (solid /hematological), with the exception of non-melanoma skin cancer.
- •Functional classification state between 0-3, according to Eastern Cooperative Oncology Group.
- •Admission to intensive care unit, because of one or more of the following criteria:
- •Invasive or non-invasive ventilatory support due to acute respiratory failure.
- •Use of vasopressor drugs due to hypotension defined as noradrenaline requirement higher than 0.1 microgram/Kg/min.
- •Renal replacement therapy due to acute renal failure.
排除标准
- •Absence of cancer recurrences in more than 5 years after diagnosis
- •Functional classification state of 4, according to Eastern Cooperative Oncology Group.
结局指标
主要结局
Mortality at 30 days
时间窗: 30 days since ICU admission
次要结局
- Mortality at 180 days(180 days since ICU admission)