NCT02373969已完成不适用
Thromboelastogram During Surgery for Total Knee Replacement With Tourniquet Application and Single Dose Tranexamic Acid
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 主要终点
- Change in coagulation status during and after surgery compared to pre-surgery
研究概览
简要总结
Verify the changes in coagulation system during total knee replacement surgery with tranexamic acid single bolus infusion.
详细描述
The study was set to reveal changes in the coagulation and fibrinolytic systems during total knee surgery and especially during tourniquet placement, tourniquet removal and revascularization of ischemic limb, after tranexamic acid single bolus infusion, and at post operative day 1.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Osteoarthrosis
- •TKR operation elective
- •ASA I-III
排除标准
- •TKR due to any reason but osteoarthrosis
- •known coagulation problems
- •platelets < 100,000/DcL
- •Hb < 12 g%
- •past thrombo-embolic event
- •treatment with aspiring during last week
- •treatment with NSAID's during last 48 hours
- •malignancy
- •known allergy to tranexamic acid
- •general anesthesia
结局指标
主要结局
Change in coagulation status during and after surgery compared to pre-surgery
时间窗: During and after surgery compared to pre-surgery
Change in fibrinolytic activity during and after surgery compared to pre-surgery
时间窗: During and after surgery compared to pre-surgery
次要结局
未报告次要终点
研究者
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