The Effect of Acute Sodium Bicarbonate Supplementation on Buffering Potential Kinetics, Physical Capacity and Discipline-Specific Performance
试验速览
- 阶段
- 3 期
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Changes in anaerobic capacity after sodium bicarbonate supplementation and placebo treatment
研究概览
简要总结
The purpose of this study is to verify the effect of acute sodium bicarbonate (SB) and placebo (PLA) supplementation on buffering potential kinetics, physical capacity, discipline-specific performance as well as concentration of diagnostically significant blood biochemical indices in athletes, in a randomised, double-blind, placebo-controlled crossover trial.
详细描述
Effective muscle work is conditioned by maintaining the proper range of muscles pH, regulated by buffering systems, in which the main role is played by bicarbonates (HCO3-). For this reason, sodium bicarbonate (SB) is often proposed as an ergogenic agent, especially during high-intensity efforts. Until now the major limitation to SB supplementation has been the gastrointestinal (GI) side effects. There is also a lack of data of the individual SB-induced changes of buffering potential kinetics and its actual connection with physical capacity and discipline-specific performance. Therefore, this study aims to examine the effect of acute, different-dose SB ingestion on buffering potential kinetics, physical capacity, discipline-specific performance as well as changes of diagnostically significant blood biochemical indices concentration in athletes, in a randomised, double-blind, placebo-controlled crossover trial.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •written consent to participate,
- •a current medical clearance to practice sports,
- •training experience: at least 2 years,
- •minimum of 4 workout sessions (in the discipline covered by the study) a week.
排除标准
- •current injury,
- •any health-related contraindication,
- •declared general feeling of being unwell,
- •unwilling to follow the study protocol.
结局指标
主要结局
Changes in anaerobic capacity after sodium bicarbonate supplementation and placebo treatment
时间窗: Baseline and during 1 day of acute SB and PLA supplementation
The Wingate cycling test carried out at baseline, and after SB and PLA supplementation
Changes of bicarbonate concentration in blood after sodium bicarbonate supplementation and placebo treatment
时间窗: Baseline and during 1 day of acute SB and PLA supplementation
Bicarbonate (HCO3-) \[mmol/L\] concentration analysis in blood carried out at baseline, and after SB and PLA supplementation
Changes in discipline-specific exercise capacity after sodium bicarbonate supplementation and placebo treatment
时间窗: Baseline and during 1 day of acute SB and PLA supplementation
The discipline-specific exercise capacity tests carried out at baseline, and after SB and PLA supplementation
Changes of base excess concentration in blood after sodium bicarbonate supplementation and placebo treatment
时间窗: Baseline and during 1 day of acute SB and PLA supplementation
Base excess \[mmol/L\] concentration analysis in blood carried out at baseline, and after SB and PLA supplementation
次要结局
- Changes of pH in blood after sodium bicarbonate supplementation and placebo treatment(Baseline and during 1 day of acute SB and PLA supplementation)
- Changes of lactate concentration in blood after sodium bicarbonate supplementation and placebo treatment(Baseline and during 1 day of acute SB and PLA supplementation)
- Changes in blood glucose concentration after sodium bicarbonate supplementation and placebo treatment(Baseline and during 1 day of acute SB and PLA supplementation)
- Changes of lactate dehydrogenase activity in blood after sodium bicarbonate supplementation and placebo treatment(Baseline and during 1 day of acute SB and PLA supplementation)
- Changes of creatine kinase activity in blood after sodium bicarbonate supplementation and placebo treatment(Baseline and during 1 day of acute SB and PLA supplementation)
- Changes of pyruvate concentration in blood after sodium bicarbonate supplementation and placebo treatment(Baseline and during 1 day of acute SB and PLA supplementation)
- Changes in hemoglobin concentration after sodium bicarbonate supplementation and placebo treatment(Baseline and during 1 day of acute SB and PLA supplementation)
- Changes of blood cells concentration in blood after sodium bicarbonate supplementation and placebo treatment(Baseline and during 1 day of acute SB and PLA supplementation)
研究者
Krzysztof Durkalec-Michalski
Principal Investigator
Poznan University of Physical Education