Evaluating the Influence of Apnea on Heart Function With Strain Analysis and Measurement of Fibrosis Derived From T1-mapping Using Cardiac Magnetic Resonance Imaging (MRI).
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 17
- 主要终点
- Cardiac Function: Duration of Apnea
研究概览
简要总结
Former studies revealed a distinct pattern of changes in circulation during deliberate apnea. Blood pressure rises significantly often accompanied by bradycardia. Further studies confirmed a massive increase of total vascular resistance as it also happens in shock to maintain perfusion of heart, lung and brain. This study is to determine the exact alterations of the cardiac function during this reaction, show the redistribution of blood volume in apnea and evaluate possible longterm effects on the central nervous system caused by repeated apnea via magnetic resonance imaging.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 16 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Being able to hold breath deliberately at least 4,5 minutes
排除标准
- 未提供
研究组 & 干预措施
Deliberate Apnea Group
Subjects undergo maximum apnea.
干预措施: magnetic resonance imaging (MRI) (Device)
结局指标
主要结局
Cardiac Function: Duration of Apnea
时间窗: every minute under apnea (from 0 up to 9 minutes and rest) depending on personal best with a mean of 5 measurements
Alteration of cardiac function in subjects undergoing maximum apnea.
Mean Blood Flow Measurement Under Apnea Using MRI
时间窗: Every minute under apnea (from 0 up to 9 minutes and rest) depending on personal best with a mean of 5 measurements
Blood flow pattern in subjects undergoing maximum apnea.
次要结局
未报告次要终点
研究者
Jonas Doerner
MD
University Hospital, Bonn