Loss of Depotentiation in Focal Dystonia
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 6
- 试验地点
- 1
- 主要终点
- MEP amplitude immediately after the PAS25-cTBS150 (depotentiation) protocol
研究概览
简要总结
Background
Focal dystonia is a brain disorder. It affects a muscle or muscles in a specific part of the body. Researchers think it may be related to excessive training or practice. They want to know more about how much training might trigger focal dystonia.
Objectives:
To study why people develop focal dystonia. To study how brain plasticity changes with focal dystonia.
Eligibility:
People at least 18 years of age with focal dystonia.
Healthy volunteers the same age are also needed.
Design:
Participants will be screened with a physical exam and questions. They may have blood and urine tests.
Participants will have up to 3 testing visits.
Participants will have small electrodes stuck on the skin on the hands or arms. Muscle activity will be recorded.
Participants will have transcranial magnetic stimulation (TMS). A wire coil will be placed onto the scalp. A brief electrical current will pass through the coil. The current will create a magnetic field that affects brain activity.
Participants may be asked to tense certain muscles or do simple actions during TMS.
A nerve at the wrist will get weak electrical stimulation. The stimulation may be paired with TMS for very short times.
Participants will receive repeated magnetic pulses. Participants will receive a total of 150 pulses during a 10-second period. An entire testing visit will last about 3 hours.
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详细描述
Objectives
Simulation paradigms can induce plastic changes in brain excitability. Paired associative stimulation (PAS) with an interstimulus interval of 25 ms (PAS25) induces a long-term potentiation (LTP)-like effect while that at an interval of 10 ms (PAS10) induces a long-term depression (LTD)-like effect. The LTP-like effect induced by PAS25 is exaggerated in patients with focal dystonia. The LTD-like effect with PAS10 is also increased in focal dystonia but not in the target area of PAS. Depotentiation refers to the reversal of LTP by which LTP is abolished by a following procedure that has no effect when it is given alone. Brain-derived neurotrophic factor has a variety of roles in modulating both LTP and LTD. The Val66Met single nucleotide polymorphism is related to abnormal cortical plasticity. In this protocol, we propose a study to test the hypothesis that depotentiation is weaker in focal dystonia patients compared to healthy controls. In addition, motor cortical inhibition is decreased in focal dystonia. We will test the changes in motor cortical inhibition following different interventional procedures in focal dystonia. We will also test the relationship between depotentiation and LTP/LTD-like effects in focal dystonia patients.
Study population
We intend to study up to 20 patients with focal dystonia and 20 age-matched healthy volunteers. Subjects will complete up to 3 study visits involving 3 different interventional procedures. Various outcome measures will be performed during each study visit.
Design
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
MEP amplitude immediately after the PAS25-cTBS150 (depotentiation) protocol
时间窗: throughout
compare MEP amplitude in patients with that in healthy volunteers to identify whether depotentiation is weaker in focal dystonia
次要结局
- MEP amplitudes(throughout)