Coronary Artery Bypass Surgery After Myocardial Infarction: Identifying Clinical Outcomes by Analysing the Senescence Associated Secretory Phenotype
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- Increase in senescent myocardial cells and senescence-associated secretory phenotype (SASP).
研究概览
简要总结
The investigators of this study have found that after a heart attack, some heart cells rapidly age (become senescent) and release proteins that make the heart disease worse.
The investigators of this study would like to check for these aged-cell proteins in participants who have coronary artery bypass graft (CABG) surgery after a recent heart attack or to treat more stable heart disease.
The investigators will do this by taking blood samples and a sample of normally discarded heart tissue from each group of participants. This might help tell us who is at the highest risk of developing heart disease and how people recover from a heart attack.
详细描述
The goal of this observational study is to compare the levels of aged-cell proteins in participants who have coronary artery bypass graft (CABG) surgery after a recent heart attack or to treat more stable heart disease.
The main questions it aims to answer are:
- To identify if there is an increased in aged-cell proteins in participants who have had a myocardial infarction and are having CABG surgery, compared to participants who are having CABG surgery for more stable heart disease.
- To establish if levels of these aged-cell proteins can predict outcomes for these patients, and if they correlate with other markers of heart disease.
The investigators will do this by taking blood samples and a sample of normally discarded heart tissue from each group of participants. This might help inform who is at the highest risk of developing heart disease and how patients recover from a heart attack.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male and female patients aged 40 to 80 years old undergoing coronary artery bypass graft surgery for myocardial infarction or for stable angina.
排除标准
- •patients with ST-elevation myocardial infarction requiring coronary angioplasty
- •patients who have had previous cardiac surgery
- •patients who have evidence of ongoing heart failure,
- •a left ventricular ejection fraction of less than 30%
- •need for pre-operative mechanical cardiac support.
- •Individuals with pre-existing acute kidney injury
- •>Stage 4 chronic kidney disease
结局指标
主要结局
Increase in senescent myocardial cells and senescence-associated secretory phenotype (SASP).
时间窗: From baseline to 6 weeks.
Blood samples taken to measure expression of a range of biomarkers.
次要结局
- Correlation of senescence and SASP with clinical outcomes(From baseline to 6 weeks)
- Progression of chronic cardiovascular disease(baseline to 6 weeks)
- Clinical outcomes post surgery(Baseline to 6 weeks)