Quantification of Myocardial Blood Flow by Positron Emission Tomography in Healthy Volunteers
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Absolute myocardial blood flow at rest and stress in cc/min/g
研究概览
简要总结
To establish quantitative values of myocardial blood flow (MBF) in normal, healthy volunteers .
详细描述
We seek to establish quantitative values of myocardial blood flow in 20 normal, healthy volunteers using our existing 2D PET camera (Positron Attrius) and invasively validated software package (HeartSee) in order to 1) establish institutional values for which clinical patients can be compared to and 2) add to the collective data of the scientific community. Values to be measured will be resting myocardial blood flow (MBF), stress MBF and coronary flow reserve.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adults ≥18 and <40 years old
- •Participants must be able to give informed consent.
- •Ability to abstain from caffeine for 48 hours
排除标准
- •Any chronic cardiac disease or condition (e.g. hypertension, hyperlipidemia)
- •Any chronic systemic disease or condition (e.g. diabetes, systemic lupus, rheumatoid arthritis)
- •Tobacco use
- •Family history in a first degree relative with clinical coronary artery disease (history of myocardial infarctio, percutaneous intervention or coronary artery bypass grafting) in men <55 years old or women <65 years old
- •Severe claustrophobia
- •Positive urine pregnancy test
- •Inability to give informed consent
结局指标
主要结局
Absolute myocardial blood flow at rest and stress in cc/min/g
时间窗: measured at the time of the cardiac PET stress scan
resting and stress MBF are in units of cc/min/g
次要结局
未报告次要终点
研究者
Robert Bober, M.D.
Director of Cardiac Molecular Imaging
Ochsner Health System