Myocardial Blood Volume Measurement by Real-Time Myocardial Perfusion Echocardiography Correlates to Myocardial Compressibility by Cardiac Magnetic Resonance Imaging in Healthy Subjects

Not Applicable

Completed

• Conditions: Healthy Adults
• Interventions: Diagnostic Test: Real-Time Myocardial Echocardiography (RTMPE); Diagnostic Test: Magnetic resonance image (MRI)

• Registration Number: NCT04724304
• Lead Sponsor: Mayo Clinic

Brief Summary

This study is being done to find out the normal amount of blood within the heart muscle and the variations in this blood flow between a cardiac MRI and TTE.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-01-22
• Study First Submitted QC: 2021-01-22
• Study First Posted: 2021-01-26
• Study Start: 2021-02-09
• Primary Completion: 2021-11-11
• Study Completion: 2021-11-11
• Status Verified: 2022-04
• Last Update Submitted: 2022-04-06
• Last Update Posted: 2022-04-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 115

Inclusion Criteria

• Age ≥ 18 years.
• Available for testing performed in Rochester, MN.
• Willing to undergo both an echocardiogram with RTMPE and CMR.
• Study subject providing consent.

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Exclusion Criteria

• Adults < 18 years.
• BMI <30 kg/m^2.
• Hypertension.
• Diabetes Mellitus.
• Stroke.
• Cardiomyopathy or structural heart disease.
• Known coronary artery disease or history of myocardial infarction.
• Contraindication to echo enhancement agent or gadolinium administration such as an allergy.
• Renal GFR < 50 mL/mL.
• Females who are pregnant.
• Subject unwilling to consent.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Healthy adults	Magnetic resonance image (MRI)	Healthy adults will have blood flow to the heart evaluated using s Real-Time Myocardial Echocardiography (RTMPE) and magnetic resonance image (MRI) to the heart.
Healthy adults	Real-Time Myocardial Echocardiography (RTMPE)	Healthy adults will have blood flow to the heart evaluated using s Real-Time Myocardial Echocardiography (RTMPE) and magnetic resonance image (MRI) to the heart.

Primary Outcome Measures

Name	Time	Method
Myocardial blood volume	Baseline	Ratio in systole and diastole (MBVs/MBVd) by real-time myocardial perfusion echocardiography (RTMPE)

Trial Locations

Locations (1)

Mayo clinic Rochester; 🇺🇸 Rochester, Minnesota, United States