Evaluation of Myocardial Perfusion and Microvascular Reserve in Real-time Utilizing Myocardial Contrast Echocardiography in Type 2 Diabetes.
Overview
- Phase
- Phase 1
- Status
- Completed
- Enrollment
- 61
- Primary Endpoint
- myocardial blood flow velocity, myocardial blood flow reserve
Overview
Brief Summary
The investigators aimed to evaluate microvascular circulation with novel method: real-time myocardial contrast echocardiography in patients with type 2 diabetes and normal coronary arteries.
Myocardial blood flow reserve will be determined by quantitative contrast Stress echocardiography. Diabetic individuals will be evaluate in a decompensated state (Phase 1) and after optimization of medical treatment four months later (Phase 2).
Detailed Description
Early stages of epicardial atherosclerosis in patients with type 2 diabetes are associated with an impairment in endothelium-dependent dilation of the coronary microvasculature, indicating that the pathophysiological consequences of atherosclerosis may extend into the coronary microcirculation.
The investigators will evaluate three parameters of myocardial quantification with contrast Stress echocardiography and correlate with HbA1C levels.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Single Group
- Primary Purpose
- Diagnostic
- Masking
- Single (Investigator)
Eligibility Criteria
- Ages
- 30 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Type 2 diabetes mellitus
- •Normal echocardiogram
- •Absence of obstructive epicardial coronary disease
Exclusion Criteria
- •Obstructive coronary disease
- •Heart valve disease
- •Cardiac Arrhythmias
- •Cardiomyopathy
Arms & Interventions
Diabetes
Type 2 diabetes patients without obstructive coronary disease. Interventional group: lifestyle changes and treatment with metformin.
Intervention: Metformin (Drug)
Outcomes
Primary Outcomes
myocardial blood flow velocity, myocardial blood flow reserve
Time Frame: 3 months
Secondary Outcomes
No secondary outcomes reported