Myocardial Perfusion in Type 2 Diabetes
- Registration Number
- NCT01043965
- Lead Sponsor
- University of Sao Paulo General Hospital
- Brief Summary
The investigators aimed to evaluate microvascular circulation with novel method: real-time myocardial contrast echocardiography in patients with type 2 diabetes and normal coronary arteries.
Myocardial blood flow reserve will be determined by quantitative contrast Stress echocardiography. Diabetic individuals will be evaluate in a decompensated state (Phase 1) and after optimization of medical treatment four months later (Phase 2).
- Detailed Description
Early stages of epicardial atherosclerosis in patients with type 2 diabetes are associated with an impairment in endothelium-dependent dilation of the coronary microvasculature, indicating that the pathophysiological consequences of atherosclerosis may extend into the coronary microcirculation.
The investigators will evaluate three parameters of myocardial quantification with contrast Stress echocardiography and correlate with HbA1C levels.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 61
- Type 2 diabetes mellitus
- Normal echocardiogram
- Absence of obstructive epicardial coronary disease
- Obstructive coronary disease
- Heart valve disease
- COPD
- Cardiac Arrhythmias
- Cardiomyopathy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Diabetes Metformin Type 2 diabetes patients without obstructive coronary disease. Interventional group: lifestyle changes and treatment with metformin.
- Primary Outcome Measures
Name Time Method myocardial blood flow velocity, myocardial blood flow reserve 3 months
- Secondary Outcome Measures
Name Time Method