Development of Clinical Assessment Technique Using Multi-radiotracer PET/MR in Prostate Cancer
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- accuracy of PET/MR predicting localization and staging of prostate cancer
研究概览
简要总结
To development of clinical assessment technique using multi-radiotracer positron emission tomography/magnetic resonance (PET/MR) in prostate cancer
- to establish the optimal imaging technique of PET/MR using multiple radioactive tracers for prostate cancer
- to establish the imaging biomarker using PET/MR for clinical assessment of prostate cancer and early detection of recurrent prostate cancer
详细描述
To establish the optimal imaging technique of PET/MR using multiple radioactive tracers for prostate cancer
- Recruiting 30 patients with prostate cancer ahead to radical prostatectomy
- PET/MR using 18F-choline with dedicated prostate MRI in all patients
- PET/MR using 18fluoride(F)-fluorodeoxyglucose(FDG)in all patients after 2-7 days
- PET/CT using 18F-FDG in all patient immediate after 18F-FDG PET/MR
- outcome assessment: comparison of scan time, image quality, tumor detection rate, standardized uptake values of lesions
- establishing optimal imaging technique for prostate PET/MR
To establish the imaging biomarker using PET/MR for clinical assessment of prostate cancer
- comparison of findings on PET/MR, MRI and PET/CT with pathological mapping after radical prostatectomy
- outcome assessment: accuracy of PET/MR for localization and staging of prostate cancer compared with MRI only and PET/CT only
To establish the imaging biomarker using PET/MR for early detection of recurrent prostate cancer
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •patient with prostate cancer before treatment
- •patient with prostate cancer treated
- •patient with prostate cancer recurrent
排除标准
- •patient with contraindication for MRI
- •Patient with severe renal impairment
结局指标
主要结局
accuracy of PET/MR predicting localization and staging of prostate cancer
时间窗: 1 week after radical prostatectomy
analysis of accuracy of PET/MR predicting localization and staging of prostate cancer by comparison of PET/MR findings with pathological mapping images after radical prostatectomy
次要结局
- accuracy of early detection and localization of recurrent prostate cancer(1 week after PET/MR imaging)
