适应症
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- No outcome measures for this study, this is an imaging study only
研究概览
简要总结
To examine the influence of current daily tobacco smoking on brain activation during stress, tobacco cue, and neutral relaxing conditions
详细描述
Subjects will participate in an fMRI session to examine changes in frontal and limbic brain regions with tobacco cues, stress and neutral/relaxing imagery. During each fMRI session subjects will participate in six imagery trials: 2 different neutral/relaxing, 2 different stress and 2 different tobacco cue scripts.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age 18-50 years inclusive;
- •able to read and write English;
- •for women, being in follicular phase of menstrual cycle;
- •Tobacco dependent sample: smokes 10 or more cigarettes daily for the past year; Non-smokers, no tobacco consumption for more than one year and never having used tobacco daily.
排除标准
- •any major neurological illness or injury and any current or prior clinically significant mental health (including PTSD) or substance use disorder (with possible exception of nicotine dependence) as determined by SCID interview;
- •use of any psychoactive medication within past four weeks;
- •any significant unstable medical condition such as asthma or heart disease for which increased cardiovascular reactivity during stress challenge might constitute a significant risk;
- •IQ<70 based on past intelligence testing;
- •any metal in body that would pose a risk with MRI; and
- •claustrophobia that would interfere with MRI;
- •alcohol and drug use in the 72 hours prior to scanning, with the exception of tobacco;
- •pregnancy for women.
结局指标
主要结局
No outcome measures for this study, this is an imaging study only
时间窗: Upon study completion
次要结局
未报告次要终点
研究者
研究点 (1)
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