Investigation of the Effect of Action Observation Training With 3D Virtual Reality on Upper Extremity Functions in Patients With Multiple Sclerosis With Attacks
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- nine hole peg test
研究概览
简要总结
Multiple sclerosis is a chronic, autoimmune and inflammatory disease of the Central Nervous System characterized by neuronal demyelination and axonal degeneration. Upper extremity problems are present in MS patients from an early stage, affecting the performance of the individual and leading to a decrease in activity of daily living ability in proportion to the extent of the problem. Action Observation Training is currently being examined as one of the methods used for the improvement of motor disorders and has been shown in the literature to be effective on different functions in neurological diseases.
The aim of this study was to investigate the effects of action observation training with 3D virtual reality on upper extremity functions, fatigue, cognitive functions, activities of daily living and quality of life in MS patients.
Hypothesis 1: Action observation training with 3D virtual reality has an effect on upper extremity functions in MS patients.
Hypothesis 2: Action observation training with 3D virtual reality has an effect on cognitive function in MS patients.
Hypothesis 3: Action observation training with 3D virtual reality has an effect on fatigue in MS patients.
Hypothesis 4: Action observation training with 3D virtual reality has an effect on activities of daily living in MS patients.
Hypothesis 5: Action observation training with 3D virtual reality has an effect on quality of life in MS patients.
详细描述
The training will involve watching 3D videos of upper limb functions in VR and then repeating the functions by the participants. The AOT group will watch video sequences involving upper limb functions, while the control group will watch landscape videos that are not likely to elicit activity in motor or ANS areas.
In our study, 3D videos of upper limb functions will be recorded with a 360° camera and will be shown to individuals through the VR system from the primary person's perspective.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •< 2 years MS diagnosis according to McDonald criteria
- •between 3.5 and 6 the EDSS
- •Nine Hole Peg Test > 30s for at least one upper extremity
- •no change in medication in the last 6 months
- •having MS disease with ongoing attacks
- •>2 Modified Ashworth Scale in the upper extremities
排除标准
- •diagnosed with neurological (except MS), cardiopulmonary, metabolic or musculoskeletal disease that would prevent treatment and evaluation
- •receiving botulinum toxin treatment in the last 6 months
- •visual impairment uncorrected by optical devices
- •inability to adapt to treatment based on 3D immersive virtual reality (e.g. with cognitive impairment, communication problems, psychological problems or vestibular system problems)
研究组 & 干预措施
Intervention Group
action observation and upper extremity activities
干预措施: Action observation training (Behavioral)
Control Group
sham action observation and upper extremity activities
干预措施: sham action observation training (Behavioral)
结局指标
主要结局
nine hole peg test
时间窗: baseline and 6th week
upper extremity function assessment
Box and Block Test
时间窗: baseline and 6th week
upper extremity function assessment
hand dynamometer
时间窗: baseline and 6th week
grip strength assessment
次要结局
- Fatigue severity scale(baseline and 6th week)
- Paced Auditory Serial Addition Test(baseline and 6th week)
- The Arm Function in Multiple Sclerosis Questionnaire(baseline and 6th week)
- Multiple Sclerosis Quality of Life-54(baseline and 6th week)
研究者
Tuba Kaya Benli
lecturery
Abant Izzet Baysal University