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临床试验/NCT04852133
NCT04852133已完成不适用

Feasibility and Reliability of Ultrasound Assessment of Muscle Architecture in Acute Burns.

Universiteit Antwerpen2 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2020年5月4日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
20
试验地点
2
主要终点
Reliability

研究概览

简要总结

This trial investigates the feasibility and reliability of different ultrasound protocols to determine quadriceps muscle architecture in acutely admitted burn patients. The results of this trial will provide more clarity as to whether ultrasound can be used as a bedside tool to monitor muscle wasting.

详细描述

BACKGROUND Despite the ubiquity of muscle wasting following burns, practical and accurate tools to measure the degree of muscle wasting are lacking in burn care. Ultrasound has been used for this purpose in the critically-ill population and has shown to be valid and reliable. Whether this can be extrapolated to the burn population, however, remains unclear. Open wounds, fluid status, and uncertainty regarding which protocol to use are amongst factors that complicate the use of ultrasound during the acute phase of burns.

AIM This study examines the reliability and feasibility of ultrasound measures in the acute burn setting comparing different techniques and locations of application.

METHODS Burned adults were assessed at admission in two Belgian burn centers by two trained assessors using B-mode ultrasound with a linear transducer. Ultrasound-derived variables included quadriceps muscle layer thickness (QMLT) and rectus femoris cross-sectional area (RF-CSA) on both thighs. Both maximum and minimum compression techniques were used for QMLT, while RF-CSA was determined by minimum compression only. QMLT was measured at a proximal and distal location on the thigh, and RF-CSA was measured at the most proximal location possible where the entire muscle belly still remained visible.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Cross Sectional

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • ≥10 - ≤80 %TBSA
  • Burn depth: 2nd deep / 3rd degree

排除标准

  • Electrical burn (except flash burns)
  • Associated injury: fracture lower limb
  • Diabetes Mellitus type 1
  • Central / peripheral neurological/neuromuscular disorders (interfering with exercise)
  • Cognitive / psychological disorders (interfering with cooperation)
  • Cardiopulmonary disease (interfering with exercise safety)
  • Pregnancy
  • Palliative care
  • Healthy subjects:

结局指标

主要结局

Reliability

时间窗: <72 hours of admission

Interrater reliability of QMLT and RF-CSA assessed by intraclass correlation

次要结局

  • Feasibility of measurements(<72 hours of admission)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Ulrike Van Daele

Full Professor

Universiteit Antwerpen

研究点 (2)

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