NCT01350427已完成不适用
Effects of Leucine, Branched-chain Amino Acids, and Resistance Exercise on Skeletal Muscle Remodelling Signaling Pathways: a Randomized, Double-blind, and Placebo-controlled Study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 2
- 主要终点
- Protein synthesis
研究概览
简要总结
This study aims to evaluate the effects of leucine and branched-chain amino acids supplementation on skeletal muscle remodeling signaling pathways induced by resistance exercise.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Sedentaries
- •Must be able to exercise
- •Must be able to swallow tablets
排除标准
- •Use of nutritional supplements
- •Use of anti-inflammatory drugs
结局指标
主要结局
Protein synthesis
时间窗: 1 hour
Phosphorylation of proteins involved in protein synthesis
Protein degradation
时间窗: 1 hour
Expression of protein involved in proteolytic pathway
Inflammation
时间窗: 1 hour
Expression of systemic and muscular cytokines
次要结局
未报告次要终点
研究者
Humberto Nicastro
PhD
University of Sao Paulo
研究点 (2)
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