临床试验/NCT01350427

NCT01350427已完成不适用

Effects of Leucine, Branched-chain Amino Acids, and Resistance Exercise on Skeletal Muscle Remodelling Signaling Pathways: a Randomized, Double-blind, and Placebo-controlled Study

University of Sao Paulo1 个研究点分布在 1 个国家目标入组 18 人开始时间: 2011年8月1日最近更新: 2013年2月25日

适应症

干预措施

试验速览

阶段: 不适用
状态: 已完成
发起方: University of Sao Paulo
入组人数: 18
试验地点: 1
主要终点: Protein synthesis

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

This study aims to evaluate the effects of leucine and branched-chain amino acids supplementation on skeletal muscle remodeling signaling pathways induced by resistance exercise.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Parallel
主要目的: Basic Science
盲法: Double (Participant, Investigator)

入排标准

年龄范围: 18 Years 至 30 Years（Adult）
性别: Male
接受健康志愿者: 是

入选标准

•Sedentaries
•Must be able to exercise
•Must be able to swallow tablets

排除标准

•Use of nutritional supplements
•Use of anti-inflammatory drugs

研究组 & 干预措施

Leucine

Experimental

干预措施: Leucine supplementation (Dietary Supplement)

BCAA

Experimental

干预措施: BCAA supplementation (Dietary Supplement)

Placebo

Placebo Comparator

干预措施: Alanine supplementation (Dietary Supplement)

结局指标

主要结局

Protein synthesis

时间窗: 1 hour

Phosphorylation of proteins involved in protein synthesis

Protein degradation

时间窗: 1 hour

Expression of protein involved in proteolytic pathway

Inflammation

时间窗: 1 hour

Expression of systemic and muscular cytokines

次要结局

未报告次要终点

研究者

发起方

University of Sao Paulo

申办方类型

Other

责任方

Principal Investigator

主要研究者

Humberto Nicastro

PhD

University of Sao Paulo

研究点 (1)

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