Dexamethasone and Dexmedetomidine as Adjuvants to Ropivacaine in Ultrasound-guided Multilevel Thoracic Paravertebral Block for Lobectomy: A Prospective, Randomized, Triple-blind Study
试验速览
- 阶段
- 4 期
- 入组人数
- 90
- 主要终点
- the duration of analgesia
研究概览
简要总结
The hypothesis is whether perineural dexamethasone and dexmedetomidine prolonged the duration of analgesia as compared with either perineural dexamethasone or perineural dexmedetomidine after TPVB.
详细描述
Design: A prospective, randomized, controlled study Setting: Single-center university hospital. Participants: The study included 90 patients undergoing lobectomy under general anesthesia.
Interventions: The patients were allocated randomly into the following 3 groups: 20 ml mixture of 37.5 mg ropivacaine with 5 mg dexamethasone (RS group) or 1 µg/kg dexmedetomidine (RM group), or with 1 µg/kg dexmedetomidine and 5 mg dexamethasone (RSM group). Ultrasound-guided TPVB was performed at 4 points-T4-5, T5-6, T6-7, and T7-8 of the surgical side; 5 mL of solution were injected at each point. Postoperatively, the PCIA was used as part of multimodal analgesia, and all patients recieve .
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 16 Years 至 65 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA physical status I-II grade Undergoing elective lobectomy under general anesthesia. Participants aged from 16-65 years old.
排除标准
- •Refusal for TPVB Inability to obtain informed consent Coagulation disorders, neuropathy, or body mass index greater than 40 kg/m2 Pregnancy Infections at the site of injection for the TPVB Allergy to dexamethasone; dexmedetomidine; ropivacaine Clinically significant cardiovascular, pulmonary, renal, or hepatic diseases
研究组 & 干预措施
RS group
20 ml mixture of 37.5 mg ropivacaine with 5 mg dexamethasone
干预措施: dexamethasone; dexmedetomidine; ropivacaine (Drug)
RM group
20 ml mixture of 37.5 mg ropivacaine with 1 µg/kg dexmedetomidine
干预措施: dexamethasone; dexmedetomidine; ropivacaine (Drug)
RSM group
20 ml mixture of 37.5 mg ropivacaine with 1 µg/kg dexmedetomidine and 5 mg dexamethasone (RSM group)
干预措施: dexamethasone; dexmedetomidine; ropivacaine (Drug)
结局指标
主要结局
the duration of analgesia
时间窗: 48 hours after surgery
time from completion of TPVB operation to VAS more than 3
次要结局
- total sufentanil consumption(48 hours after surgery)
- VAS(1, 2, 4, 8, 12, 24, 36, and 48 hours after surgery)
- adverse effects(48 hours after surgery)
研究者
dong zhang
dong zhang
Gansu Provincial Hospital