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临床试验/NCT03313817
NCT03313817已完成不适用

Pre and Post-arterial Recanalization Imaging of Central Retinal Artery Occlusions (CRAO)

Fondation Ophtalmologique Adolphe de Rothschild1 个研究点 分布在 1 个国家目标入组 63 人开始时间: 2017年12月13日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
63
试验地点
1
主要终点
Contrast enhancement of the ophthalmic artery

研究概览

简要总结

Central retinal artery occlusions (CRAO) are the equivalent of an ischemic stroke at the retinal level. They share the same risk factors and common pathology. The diagnosis of a CRAO is clinically based on the sudden occurrence of a decrease in deep visual acuity with fundamentally signs of reactive ischemia.

Small studies have highlighted the value of cerebral MRI (Magnetic Resonance Imaging) in CRAO with almost 25% of ischemic strokes found on diffusion sequences and the demonstration of a correlation between anomalies in diffusion sequence and the probability of a pathology with a high risk of recurrence (carotid stenosis or emboligenic cardiopathy). But there are usually few radiological signs that allow a direct positive diagnosis of CRAO, an etiologic diagnosis or a prognosis. This descriptive study will focus on CRAO at the diagnostic and post-treatment phases in the short and medium term, in order to (i) identify imaging etiologic signs of CRAO with specific sequences from a 3 Tesla MRI, (ii) identify positive diagnostic signs of CRAO with the same specific sequences, (iii) correlate these signs with the visual prognosis one month after the CRAO.

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • 18 years of age or older
  • CRAO (onset of symptoms ≤ 48 hours)
  • Consent to participate in the study

排除标准

  • - Contraindications to 3 Tesla MRI

结局指标

主要结局

Contrast enhancement of the ophthalmic artery

时间窗: Baseline

Binary variable (yes/no)

Presence of a thrombus

时间窗: Baseline

Binary variable (yes/no)

Restriction of the apparent diffusion coefficient (ADC) at the optic nerve level and at the papilla level

时间窗: Baseline

Binary variable (yes/no)

Hypersignal of the ophthalmic artery in diffusion

时间窗: Baseline

Binary variable (yes/no)

Presence of an arterial stenosis of the supra aortic trunks

时间窗: Baseline

Binary variable (yes/no)

次要结局

未报告次要终点

研究者

申办方类型
Network
责任方
Sponsor

研究点 (1)

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