ACTRN12616000086460已完成未知
Effect of dietary nitrate supplementation on cerebrovascular health in high risk transient ischaemic attack (TIA) patients
Mickey Fan0 个研究点目标入组 36 人开始时间: 2016年1月27日最近更新:
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 36
研究概览
简要总结
We found dietary nitrate supplementation reduced blood pressure and brain blood flow fluctuations and improved the relationship between blood pressure and brain blood flow in transient ischemic attack patients. Meanwhile, dietary nitrate had no effects on the brain blood vessels’ response to CO2. We attribute the improved brain blood flow stability to the improved myogenic control of blood pressure with dietary nitrate. Our findings indicate that dietary nitrate could be an effective strategy for stabilizing blood pressure and brain blood flow following transient ischemic attack.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 20 Years 至 85 Years（—）
- 性别
- All
入选标准
- •Patient group
- •1) Those individuals aged 40-85 diagnosed as high risk TIA (with ABCD2 score greater than or equal to 4), after review by a specialist stroke physician
- •2) Those individuals living within Wellington City and the Greater Wellington region
- •Healthy group
- •1) Healthy individuals (age 20-85 years) of both sex, specifically:
- •2) Free of history of long-term disease
- •3) Not currently taking any medication that may influence measures in this study.
- •4) Those individuals living within Wellington City and the Greater Wellington region
排除标准
- •Patient group
- •1) Those individuals requiring supplementary oxygen
- •2) Individuals with allergy to nitrates
- •3) Unstable cardiac conditions or angina
- •4) Uncontrolled diabetes mellitus
- •5) Major medical conditions
- •6) Significant cognitive impairment
- •7) Immobility
- •Healthy group
- •1) Very high (greater than 140/90) or very low (lower than 100/60) resting blood pressure
- •2) Previous history of stroke, brain surgery, or severe head trauma
- •3) Pregnancy
研究者
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