NCT07795710已完成不适用
A Comparative Study of Intermittent Bolus Doses of Phenylephrine, Norepinephrine and Ephedrine for the Management of Spinal Induced Hypotension in Preeclamptic Patients
Minia University1 个研究点 分布在 1 个国家目标入组 150 人开始时间: 2024年1月30日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Heart rate changes
研究概览
简要总结
intermittent bolus doses of phenylephrine, norepinephrine and ephedrine for the management of spinal induced hypotension in preeclamptic patients
详细描述
A Comparative study of intermittent bolus doses of phenylephrine, norepinephrine and ephedrine for the management of spinal induced hypotension in preeclamptic patients
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Preeclamptic pregnant female
- •ASA II and III
- •singleton or twin pregnancies will be scheduled for caesarean delivery
- •diagnosis of preeclampsia as a new onset of hypertension and proteinuria.
排除标准
- •chronic hypertension, labor or failed trial of labor,
- •body mass index ≥40 kg/m2 ,
- •resting heart rate <60 bpm, eclampsia,
- •known fetal anomalies, contraindications to spinal anesthesia, abruption placentae, and cord prolapas.
研究组 & 干预措施
Group 1 (phenyelepherine group)
Experimental
receive bolus dose of phenyelepherine 75 ug
干预措施: Group 1 (P) (Drug)
Group 2 ( noradrenaline group)
Experimental
receive bolus dose of noradrenaline 4 ug
干预措施: Group 2( N) (Drug)
Group 3 ( ephedrine group)
Experimental
receive bolus dose ephedrine 4 mg
干预措施: Group 3( E) (Drug)
结局指标
主要结局
Heart rate changes
时间窗: every 3 minutes till 40 minutes
次要结局
- Systolic blood pressure(every 3 minutes till 40 minutes)
研究者
Ali Essam
Assistant lecturer
Minia University
研究点 (1)
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