Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Migraine aura
研究概览
简要总结
The aim of the present study is to explore the importance of migraine genes on the headache/migraine responses after GTN in FHM-patients and healthy volunteers.
详细描述
Glyceryl trinitrate (GTN) induces migraine attacks indistinguishable from spontaneous attacks in approximately 80% of migraine sufferers. After systemic administration GTN is transformed to nitric oxide (NO). Treatment of spontaneous migraine attacks with an inhibitor of NO is effective in 60% of patients. These data show that NO is involved in both initiation and maintenance of migraine attack.
The importance of migraine genes is disputed. Evidence from FHM patients with known mutations indicates that migraine pathways in FHM may be different from normal migraine. The aim of the present study is to examine whether this difference also exists in FHM patients without known mutations. The project will improve our understanding of the neurobiology of migraine and stimulate development of new treatment targets.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Diagnosis of familial hemiplegic migraine (IHS-classification criteria)
排除标准
- •Patients and controls:
- •A history of cerebrovascular disease and other CNS- disease
- •A history of serious somatic and mental disease
- •A history suggesting ischaemic heart disease
- •A history of hypo- or hypertension
- •Daily intake of medication apart from oral contraceptives
- •Abuse of alcohol or medicine (opioid analgesics).
- •Pregnant or breastfeeding women.
- •On the study day:
- •No intake of a simple analgesic in the previous 48 hours
- •No headache in the previous 48 hours
研究组 & 干预措施
Patients
GTN-infusion
干预措施: Nitroglycerine (Drug)
Controls
GTN-infusion
干预措施: Nitroglycerine (Drug)
结局指标
主要结局
Migraine aura
时间窗: 0 - 14 h
Migraine and associated symptoms
时间窗: 0-14 h
次要结局
未报告次要终点