Imaging in motor neuron diseases; biomarker research with MRI - Imaging in MND

niversitair Medisch Centrum Utrecht0 个研究点目标入组 900 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•1. Patients: i) For ALS patients: definite, probable, probable-laboratory supported or possible ALS according to the revised El Escorial criteria (Brooks 2000); familial ALS is defined only if there is a family history of ALS. ii) For progressive spinal muscular atrophy (PSMA) or primary lateral sclerosis (PLS): patients with clinical diagnosis of PSMA or PLS, after excluding other diseases. iii) Patients with *ALS mimic syndromes*: patients suspected of mimic disorders (e.g. multifocal motor neuropathy, inclusion body myositis, cervical myeloradiculopathy, myasthenia gravis,
•Kennedy*s disease). 2. Age 18 - 80 years (inclusive). 3. Capable of thoroughly understanding the study information given; has signed the informed consent.

•1) Tracheostomy, tracheostomal ventilation of any type, (non)-invasive ventilation; 2 ) Any history or presence of brain injury, epilepsy, psychiatric illness and other cerebral disease; 3) Any intoxication or medication known to have an association with motor neuron dysfunction, which might confound or obscure the diagnosis of motor neuron disease; 4) Presence of pronounced swallowing disorders (which make it dangerous to lie supine in the MRI scanner); 5) Contra-indication for 3 or 7Tesla MRI imaging (as established by the department); 6) Pregnancy

发起方

niversitair Medisch Centrum Utrecht