A 8 week, randomized, double-blind, placebo-controlled clinical trial for the evaluation of the efficacy and safety of oraCMU on oral health

Seoul National University Dental Hospital0 个研究点目标入组 100 人开始时间: 待定最近更新: 2019年10月7日

试验速览

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•1) Those who voluntarily agree to participate in this study and sign in informed consent form
•2) Men and women between 20 and 70 years old
•3) Those who have 20 or more natural teeth excluding wisdom teeth
•4) Those who without tongue diseases
•5) A person with volatile sulfur compounds concentration of 1.5 ng/10 ml or more
•6) Persons without severe periodontal disease, rampant caries, less than five dental caries to be treated immediately

•1) Those who have communication problem with investigators
•2) Those who have mental diseases
•3) Those who are currently being treated with systemic disease that may cause bad breath
•4) Those who have a diagnosis of sinusitis or rhinitis
•5) Those taking antibiotics within 1 month before the first visit
•6) Those who have a diagnosis of chronic gastritis
•7) Those with uncontrolled hypertension
•8) Diabetic patients taking hypoglycemic agents
•9) Those who consume food or health functional food with probiotics within 1 week before the first visit
•10) Those who have hypersensitivity or allergy to probiotics including dairy food
•11) Those taking warfarin or aspirin
•12) Those who have aspiration risk
•13) Those who have dry mouth
•14) Persons with severe periodontal disease, rampant caries, five or more dental caries to be treated immediately
•15) Pregnant or lactating women, or with pregnancy plan during the study period
•16) Those who have participated in other clinical trials within 6 months before participating in this study
•17) Those who are deemed by the investigator to be unsuitable for this study

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