GR Defect in Sputum Cells in COPD

Imperial College London1 个研究点分布在 1 个国家开始时间: 2005年12月最近更新: 2024年4月4日

适应症

试验速览

阶段: 不适用
状态: 撤回
发起方: Imperial College London
试验地点: 1

研究概览研究设计入排标准研究者研究点记录与标识符相似试验

研究概览

简要总结

To investigate a possible mechanism of the GR defect in patients with severe COPD by studying the effect of dexamethasone (Dex) on GR-GRE binding, expression of inflammatory and anti-inflammatory factors such as IL-6, IL-8, MKP-1, GILZ, SLPI production in sputum cells

研究设计

研究类型: Observational
观察模型: Case Control
时间视角: Prospective

入排标准

年龄范围: 35 Years 至 85 Years（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Patients with moderate (stage II, GOLD) COPD or subjects who are healthy smokers or subjects who are non-smokers.
•Written informed consent

排除标准

•Current upper respiratory tract infections
•Any significant disease or disorder (e.g. cardiovascular, pulmonary (other than asthma), gastrointestinal, liver, renal, neurological, musculoskeletal, endocrine, metabolic, malignant, psychiatric, major physical impairment) which, in the opinion of the investigator, may either put the subject at risk because of participation in the study, or may influence the results of the study, or the subjects ability to participate in the study
•Subjects not considered capable, as judged by the investigator, of following instructions of the study, e.g. because of a history of alcohol or drug abuse or any other reason

研究者

发起方

Imperial College London

申办方类型

Other

责任方

Sponsor

研究点 (1)

Loading locations...

相似试验

终止

不适用

COPD Patients Diagnosed With GERD,COPD Exacerbations After Treatment With High Dose PPIChronic Obstructive Pulmonary DiseaseGastroesophageal Reflux

NCT00523367University of Florida25

已完成

不适用

Granzymes and Perforin at the Onset of Chronic Obstructive Pulmonary Disease (COPD) ExacerbationsChronic Obstructive Pulmonary Disease

NCT00883701University of Thessaly30

已完成

不适用

Pulmonary and Systemic Hepatocyte Growth Factors in Patients With COPDChronic Obstructive Pulmonary Disease

NCT00477074Hospital Universitari Son Dureta44

已完成

不适用

Regulation of Inflammatory Mediators in Chronic Obstructive Pulmonary DiseaseCOPDEmphysema

NCT00147095Imperial College London80

招募中

不适用

The role of Growth differentiation factor 11 in the pathogenesis of chronic obstructive pulmonary diseasechronic obstructive pulmonary disease (COPD)

JPRN-UMIN000019067Department of Respiratory Medicine, TohokuUniversityGraduateSchoolof Medicine300