Comparison of the Evolution of Memory Deficit in Patients With Sleep Apnea Obstructive Syndrome (SAOS) Before and After "Effective" Versus Sham Treatment by Positive Pression Continues (PPC)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
研究概览
简要总结
The main objective of this study is to evaluate the evolution of memory deficit (verbal episodic memory, procedural memory, working memory, short-term memory) in Sleep Apnea Obstructive Syndrome (SAOS) patients after treatment by Continuous Positive Airway Pressure treatment (CPAP). For thus, we will compare memory tests in two separate groups of SAOS patients with "effective " versus "ineffective" ( or sham) CPAP, before and 6 weeks after the beginning of the treatment. Thus we will assess the evolution of memory deficit, the effectiveness of the treatment on the evolution of memory deficit before and 6 weeks after the beginning of the treatment by "effective " versus "ineffective" CPAP.
We feel the results of the tests of memory will show greater memory disorders in patients with SAOS before beginning the treatment rather than six weeks afterwards. Thus we hypothesise that, after the treatment by "effective" CPAP, the patients with SAOS will have greater improvement of their memory disorders than those treated by "sham CPAP".
详细描述
We want to assess the evolution, before and 6 weeks after the beginning of the treatment, of the significant differences of the performances of the various memory tests evaluating several forms of memory (episodic memory, working memory, short-term memory and procedural memory) according to the treatment for patients with SAOS (effective versus sham).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Major patients,
- •agreeing,
- •diagnosed suffering from the SAOS,
- •regulation by the specialist in a treatment by CPAP,
- •patients do not begin the treatment
- •affiliated to the social security,
- •fluent in French.
排除标准
- •Patients presenting severe depressive disorders (HADS score>19),
- •intellectual deterioration (MMS< 28),
- •a functional failure of the dominant arm upper limb inhibiting realization of graphic tasks,
- •an associated oxygen treatment,
- •suffering from cancer,
- •cerebro-vascular accident,
- •pregnant or nursing women,
- •adult under supervision or trusteeship,
- •patients already included in another research protocol or in period of exclusion,
- •antidepressant and anxiolytic treatment.
研究组 & 干预措施
Effective CPAP treatment
Effective Continuous Positive Airway Pressure treatment (CPAP) applied for 6 weeks
干预措施: Effective CPAP (Device)
Sham CPAP treatment
Ineffective Continuous Positive Airway Pressure treatment (sham CPAP) applied for 6 weeks
干预措施: Sham CPAP (Device)