Electromechanical Profiling of Arrhythmogenic Substrates and Triggers in the Long-QT Syndrome
试验速览
- 阶段
- 不适用
- 入组人数
- 150
- 主要终点
- Differences in regional electromechanical dispersion between LQTS patients and controls
研究概览
简要总结
High-resolution, non-invasive electromechanical mapping in genotyped long-QT syndrome patients and healthy controls at baseline and during smart provocation.
详细描述
Using simultaneous ECG-imaging, speckle-tracking analysis and tissue-phase mapping with MRI we will assess electromechanical dispersion at rest. Regional electromechanical elasticity will be investigated during adenosine and epinephrine, isoprenaline infusions and is postulated to increase sudden cardiac death risk prediction in the individual patient.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •LQTS group (Group 1):
- •Diagnosis of LQTS according to the ESC guidelines.
- •Genetic testing either already performed or consent to genetic testing (at least 5 major LQTS-related genes tested: KCNQ1, KCNH2, SCN5A, KCNE1, KCNE2).
- •Control group (Group 2):
- •> Control subjects with structurally normal hearts.
排除标准
- •Pregnancy, nursing or planning to become pregnant.
- •Known allergy or strong reaction to skin electrodes or contrast agent.
- •Inability to give informed consent.
- •Presence of metal objects in or attached to the body.
- •Dialysis.
- •Cardiomyopathy.
- •Second-degree heart block or higher degrees of block.
- •Sick sinus syndrome.
- •Chronic obstructive pulmonary disease.
- •Left-main coronary artery disease.
- •Unstable coronary artery disease.
结局指标
主要结局
Differences in regional electromechanical dispersion between LQTS patients and controls
时间窗: At day of investigation
Electromechanical dispersion in milliseconds
Differences in regional electromechanical dispersion between symptomatic and asymptomatic LQTS patients
时间窗: At day of investigation
Electromechanical dispersion in milliseconds
次要结局
- Relation between global electromechanical window vs regional electromechanical dispersion in LQTS(At day of investigation)
- Correlation of electromechanical dispersion between LQTS type 1, 2, and 3.(At day of investigation)
- Correlation between mechanical dispersion using TPM-MRI and cine-MRI(At day of investigation)
- Correlation between mechanical dispersion using TPM-MRI and speckle-tracking echocardiography(At day of investigation)