The Effect of Positive End Expiratory Pressure on Central Venous Pressure Among Patients With Different Lung Compliance
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- CVP
研究概览
简要总结
To observe the effect of PEEP on CVP among patients with different respiratory compliance
详细描述
30 patients with mechanical ventilation and inserted central venous line will be entered. After gathering demographic data, patients undergone 5,10 and 15cmH2O PEEPs and the respective CVPs of the mentioned points will be recorded. According to the change of CVP, the patients will be divided into high response group and low response group, then comparing the lung compliance and thorax elastic resistance differences between the two groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with mechanical ventilation and inserted central venous line
排除标准
- •The age is less than 18 years old or more than 80 years old；
- •Pregnant and lying-in woman；
- •Patients undergoing fluid resuscitation and the speed is more than 200ml/h；
- •Patients with norepinephrine dose are greater than 15 micro per minute；
- •Patients with pericarditis、pulmonary heart disease、right heart failure、atrial fibrillation；
- •Patients with COPD(endogenous PEEP is more than 2cmH2O)、tension pneumonthorax、acute episode asthma
研究组 & 干预措施
high response group
patients undergo 5,10 and 15cmH2O positive end expiratory pressure ,the change of central venous pressure is more than 2.5cmH2O
干预措施: 5,10 and 15cmH2O positive end expiratory pressure (Other)
low response group
the change of CVP is less than 2.5cmH2O
干预措施: 5,10 and 15cmH2O positive end expiratory pressure (Other)
结局指标
主要结局
CVP
时间窗: half an hour
Measure the central venous pressure of the three level PEEPs of 5,10 and 15cmH2O.
次要结局
未报告次要终点
研究者
Jingyuan,Xu
Attending doctor
Southeast University, China