The Use of Drospirenone/Estetrol, Nomegestrol Acetate/Estradiol and Ethinylestradiol/Dienogest in Random Start Rapid Preparation of Endometrium Before Office Hysteroscopic Polypectomies: a Multicenter, Prospective, Randomized Study
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 150
- 试验地点
- 2
- 主要终点
- Quality of endometrial preparation
研究概览
简要总结
The presence of a thin endometrium plays an important role in enabling the best conditions for hysteroscopic surgery. Recently, for this purpose, many studies have evaluated the effect of preoperative administration of a variety of drugs. We explored the efficacy of random started 14-day administration of Drospirenone/Estetrol or Nomegestrol Acetate/Estradiol or Ethinylestradiol/Dienogest, in rapid preparation of endometrium for hysteroscopic polypectomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Patients with endometrial polyps.
排除标准
- •Patients with other endometrial pathologies.
研究组 & 干预措施
Drospirenone/Estetrol
Patients with endometrial polyps underwent hysteroscopic polipectomy after starting 14-day treatment with oral Drospirenone/Estetrol at any time of the menstrual cycle
干预措施: Drospirenone / Estetrol (Drug)
Nomegestrol Acetate/Estradiol
Patients with endometrial polyps underwent hysteroscopic polipectomy after starting 14-day treatment with oral Nomegestrol Acetate/Estradiol at any time of the menstrual cycle
干预措施: Nomegestrol Acetate / Estradiol (Drug)
Ethinylestradiol/Dienogest
Patients with endometrial polyps underwent hysteroscopic polipectomy after starting 14-day treatment with oral Ethinylestradiol/Dienogest at any time of the menstrual cycle
干预措施: Ethinylestradiol / Dienogest (Drug)
结局指标
主要结局
Quality of endometrial preparation
时间窗: 14th day of treatment
Quality of endometrial preparation assessed visually intraoperatively by the surgeon using a visual analog scale from 0 to 5
次要结局
未报告次要终点
研究者
Andrea Etrusco
M.D.
University of Palermo