A Comparitive study to assess efficacy of topical 0.1% betamethasone valerate versus fractional co2 laser with 0.1% topical betamethasone valerate in treatment of alopecia areata
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Hair regrowth in alopecia patches
研究概览
简要总结
Alopecia areata is a complex genetic immune mediated inflammatory non scarring hair loss that results in decrease in quality of life. It may affect any hairy area in body and is usually reversible. Alopecia areata postulated to be hair specific autoimmune disease, with genetic factors playing role in disease susceptibility and severity. In acute progressive stage of alopecia areata , lymphocytic infiltration are seen around and sometimes with in the hair bulb region of anagen follicles
Despite the presence of this inflammatory infiltrate, the follicle retains its potential to produce hair, implying that the follicular stem cells remain viable. The chronic relapsing nature of alopecia areata and its profound effect on physical appearance make the development this condition distressing and life changing event for many affected individuals
研究设计
- 研究类型
- Interventional
- 分配方式
- Random Number Table
- 盲法
- Open Label
入排标准
- 年龄范围
- 14.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patient with alopecia areata patients will be divided into Group A & Group B.
- •Each group comprising of 40 patients.
- •40 patients in Group A will be use topical 0.1% betamethasone alone 40 patients in Group B will treated with fractional co2 with topical 0.1% betamethasone.
- •Maximum 6 sittings will be given at 2 weeks interval.
排除标准
- •Before starting the study Pregnant and lactating women.
- •Women planning for pregnancy Children less than 14 years During Study If patient wants alternate treatment during the study.
- •If patient wants to discontinue the treatment.
结局指标
主要结局
Hair regrowth in alopecia patches
时间窗: 24 weeks post study
次要结局
- atrophy of skin(12 weeks post study)