Cognitive Control Training as a Preventive Intervention for Depression: A Double-blind Randomized Controlled Trial Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 68
- 试验地点
- 2
- 主要终点
- Change in depressive rumination from baseline to the post-training assessment and follow-up (RRS)
研究概览
简要总结
The purpose of this study is to explore the effectiveness of an internet-delivered cognitive control training as a preventive intervention for remitted depressed patients.
详细描述
Prospective studies have linked impaired cognitive control to increased cognitive vulnerability for future depression. Importantly, experimental studies indicate that cognitive control training can be used to reduce rumination and depressive symptomatology in MDD samples. Furthermore, studies exploring the potential of cognitive control training in at-risk undergraduate students indicate that cognitive control training has beneficial effects on rumination, an important vulnerability factor for depression. Provided that remitted depressed patients form a high-risk group for developing future depressive episodes, the current study will explore whether internet-delivered cognitive control training can be used to reduce vulnerability for future depression in remitted depressed patients. The investigators will explore effects on depressive symptomatology, (mal-)adaptive emotion regulation (directly following training and at 3 months follow-up), and indices of functioning (at 3 months follow-up).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 23 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •History of ≥ 1 depressive episode(s)
- •Currently in stable full or partial remission (≥ 6 months)
排除标准
- •Major depressive disorder (MDD; current)
- •Bipolar disorder (current and/or previous)
- •Psychotic disorder (current and/or previous)
- •Neurological impairments (current and/or previous)
- •Excessive substance abuse (current and/or previous)
- •No other comorbid disorders (current)
- •No ongoing psychotherapeutic treatment (maintenance treatment is allowed, but with a frequency less than once / 3 weeks)
- •Use of antidepressant medication is allowed if kept at a constant level
结局指标
主要结局
Change in depressive rumination from baseline to the post-training assessment and follow-up (RRS)
时间窗: baseline, 2 weeks, 3 months
Assessed using the Ruminative Response Scale (RRS)
Change in depressive symptomatology from baseline to the post-training assessment and follow-up (BDI-II)
时间窗: baseline, 2 weeks, 3 months
Assessed using the Beck Depression Inventory (BDI-II)
次要结局
- Resilience (RS)(baseline, 3 months)
- Quality of Life (QLDS)(baseline, 3 months)
- Disability (WHODAS 2.0)(baseline, 3 months)
- (mal-)Adaptive cognitive emotion regulation (CERQ)(baseline, 2 weeks, 3 months)
- Remission from depression (RDQ)(baseline, 3 months)