Salvage Living Donor Liver Transplantation for HCC Beyond All Criteria Yield Equivalent Results to Milan Criteria in High Prevalence Young HCC Patients Country.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 241
- 主要终点
- HCC recurrence
研究概览
简要总结
The present study aims to evaluate the impact of expanding criteria beyond Milan on tumor recurrence and patient survival that will help identify the best selection criteria for HCC transplanted patients.
详细描述
Introduction
HEPATOCELLULAR CARCINOMA (HCC) is the second leading cause of cancer mortality worldwide. Living donor liver transplantation (LDLT) for HCC patients has emerged as a rewarding therapy for a cure and a successful alternative where a Deceased donor liver transplantation (DDLT) program is lacking. Therefore, trials for careful expansion to Milan criteria have been adopted.
Aim of the study:
To evaluate the impact of expanding criteria beyond Milan on tumor recurrence and patient survival that will help identify the best selection criteria for HCC transplanted patients
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patient transplanted for HCC eligible for transplant (no vascular invasion-no extra hepatic metastasis)
排除标准
- •other etiology for liver transplant rather than HCC
- •patient not fit for surgery
- •age >70y
结局指标
主要结局
HCC recurrence
时间窗: 3 years
Recurrence of Hepatocellular carcinoma either intra-hepatic, extra-hepatic or both
次要结局
未报告次要终点
研究者
Manar Salah
Principal investigator
Ain Shams University